Skip to main content
. 2014 Apr 7;13:138. doi: 10.1186/1475-2875-13-138

Table 7.

Predicted time to recrudescence (in days) for artemether-lumefantrine (AM-LF) in populations of 10,000 individuals for different treatment scenarios group by dosing regimen (according to Table 2) and geographical region

Treatment scenario   Age-based dosing regimen Weight-based dosing regimen
Full course, i e, twice daily over three days at 0, 8, 24, 36, 48 and 60 hours
 Min.
 14
 12
 14
 11
 14
 12
 14
 11
1st Qu.
 22
 19
 24
 18
 22
 19
 24
 18
Median
 29
 27
 31
 28
 29
 28
 30
 28
Mean
 33
 31
 34
 30
 31
 31
 31
 29
3rd Qu.
 46
 46
 48
 44
 41
 43
 38
 38
Max.
 57
 53
 58
 52
 57
 53
 56
 52
Fifth dose missed
 Min.
 10
 8
 10
 8
 10
 8
 10
 8
1st Qu.
 17
 14
 19
 20
 17
 17
 19
 20
Median
 30
 28
 30
 35
 25
 28
 28
 36
Mean
 30
 30
 31
 32
 30
 31
 32
 33
3rd Qu.
 44
 45
 46
 43
 46
 46
 47
 43
Max.
 54
 59
 55
 57
 54
 59
 57
 57
Sixth dose missed
 Min.
 10
 8
 10
 8
 10
 8
 10
 8
1st Qu.
 17
 14
 19
 20
 17
 17
 19
 20
Median
 30
 28
 30
 35
 25
 28
 28
 36
Mean
 30
 30
 31
 32
 30
 31
 32
 33
3rd Qu.
 44
 44
 45
 43
 46
 46
 46
 43
Max.
 54
 59
 55
 57
 54
 59
 56
 57
Fifth and sixth dose missed
 Min.
 6
 5
 7
 5
 6
 5
 7
 5
1st Qu.
 25
 28
 22
 27
 19
 28
 22
 27
Median
 35
 38
 33
 38
 37
 37
 36
 38
Mean
 33
 35
 33
 36
 33
 34
 33
 35
3rd Qu.
 43
 45
 43
 45
 43
 45
 44
 45
Max.
 62
 61
 62
 60
 62
 61
 59
 60
Third, fourth, fifth and sixth dose missed
 Min.
 3
 5
 5
 3
 3
 4
 3
 3
1st Qu.
 19
 21
 23
 21
 19
 18
 18
 18
Median
 26
 30
 31
 29
 25
 25
 25
 24
Mean
 27
 30
 31
 30
 26
 26
 26
 25
3rd Qu.
 34
 39
 39
 38
 34
 33
 34
 32
Max.
 61
 61
 63
 63
 61
 63
 61
 63
Third, fourth, fifth and sixth dose delayed by 12 hours
 Min.
 14
 12
 14
 11
 14
 12
 14
 11
1st Qu.
 22
 19
 24
 18
 22
 18
 24
 18
Median
 29
 26
 31
 29
 29
 27
 30
 28
Mean
 33
 30
 34
 30
 32
 29
 31
 29
3rd Qu.
 46
 40
 48
 44
 41
 38
 38
 38
Max.
 57
 54
 58
 52
 57
 54
 56
 52
Increased IC50 by 50-fold for LF and 10-fold for AM and DHA
 Min.
 5
 5
 5
 5
 5
 5
 5
 5
1st Qu.
 15
 14
 15
 14
 15
 14
 14
 14
Median
 20
 20
 20
 20
 20
 20
 20
 20
Mean
 21
 21
 21
 20
 21
 21
 21
 20
3rd Qu.
 27
 27
 27
 26
 26
 26
 26
 26
Max.
 51
 57
 51
 62
 54
 57
 55
 55
Administered without food, i e, 50% lower dose for LF
 Min.
 11
 12
 14
 11
 11
 9
 12
 8
1st Qu.
 20
 19
 24
 18
 20
 19
 15
 18
Median
 25
 27
 31
 28
 23
 28
 24
 29
Mean
 28
 31
 34
 30
 27
 29
 27
 30
3rd Qu.
 39
 46
 48
 44
 34
 40
 34
 41
  Max. 52 53 58 52 52 48 52 49

DHA: dihydroartemisinin; IC50: Concentration producing half the desired effect; Min.: minimum; Qu.: quartile; Max.: maximum.