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Protonation state IV. (a) The interactions are depicted between active site residues and the carboxylate of benzylpenicillin. Arg285 is above His298 in the orientation show. (b) The carbonyl forms hydrogen bonds with Thr301 and Ser62. (c) Asn161, Thr301, and H2O-9 contribute to the stabilization of the benzylpenicillin tail. (d) A 2D view of the active site is shown with interactions for IV.
