Table. Gene mutations of 214 drug-resistant tubercle bacilli, Zhejiang Province, China, 2011–2012.
| Drug |
Mutant points |
Mutant times | ||
|---|---|---|---|---|
| Mutant times for single site, no. (%)* |
Total no. mutant times of sites related to drug resistance |
|||
| Isoniazid | inhA-15 (C→T) | 32 (18.6) | 172† | |
|
|
katG315 (G→C), (G→A) |
140 (81.4) |
|
|
| Rifampin | rpoB511 (T→C) | 10 (7.1) | 140‡ | |
| rpoB513 (A→C) | 2 (1.4) | |||
| rpoB516 (A→T), (A→G), (G→T) | 19 (13.6) | |||
| rpoB526 (A→G), (A→T), (C→G), (C→T) | 21 (15) | |||
| rpoB531 (C→G), (C→T) | 84 (60.0) | |||
| rpoB533 (T→C) | 4 (2.9) | |||
*No. mutant times for single site/total no. mutant times of sites related to drug resistance. †A strain simultaneously had katG315 (G→C) and inhA-15 (C→T). ‡Five strains had the double mutation of rpoB.