Table 2.
Summary of Protein Kinase Domain Containing Clusters Identified by TribeMCL
| cluster ID | riken | total | branch | cluster or branch description | Hanks' classification | domain associations | |
|---|---|---|---|---|---|---|---|
| Serine/Threonine Kinases (289) | 0.0 | 10 | 66 | SGK | serum glucocorticoid kinase | AGC-OTHER | |
| Ribos6 | Ribosomal S6 kinase | AGC-VI | |||||
| RAC | RAC | AGC-III | Pleckstrin like | ||||
| PKC | Protein kinase-C | AGC-II | PKC, C2 domain, PKN | ||||
| cNMP | cAMP/cGMP dependent PKs | AGC-I | cNMP binding | ||||
| Rho/myotonin | Rho/myotonin | AGC-VII | PKC, Pleckstrin, citron | ||||
| unknown1k | AGC-OTHER | PDZ | |||||
| aurora | aurora-related | OPK-I | |||||
| GPCR | G protein coupled receptor kinase | AGC-IV | regulator of G protein, GPCR kin | ||||
| 0.1 | 25 | 94 | death assoc | death associated kinases | CAMK-I | ||
| CAMKII | calcium/calmodulin-dependent kinase type II | CAMK-I | |||||
| CAMKI | calcium/calmodulin-independent kinase type I | CAMK-I | |||||
| unknown2k | snf1/ELKL/ink76/st22 | CAMK-II | UBQ assoc, kinassoc c-term | ||||
| unknown3k | pim | OPK-OTHER | UBQ assoc | ||||
| MAPKAPK | mitogen activated protein kinase activated protein kinase | CAMK-OTHER | |||||
| PKD/ULK | AGC-II/OPK-V | ||||||
| 0.2 | 13 | 72 | unknown4k | tousled, misc | OPK-VII/CAMK-1 | ||
| MAPK | mitogen activated protein kinase | CMGC-II | mapk | ||||
| CDK | cyclin dependent kinases | CMGC-I | |||||
| GSK, CKII | glycogen synthase kinase, casein kinase II | CMGC-OTHER/III/IV | |||||
| apop MAP3K | apoptosis regulating MAP3 kinase | OPK-IV | |||||
| 0.3 | 1 | 5 | unknown5k | OPK-OTHER | |||
| 0.4 | 13 | 52 | polo | polo like kinases | OPK_I | polo box | |
| MAP3K | mitogen activated protein kinase kinase kinase | OPK-IV | |||||
| NEK | NIMA expressed related kinases | OPK-V | |||||
| DUSP/MAP2K | dual specificity mitogen activated protein kinase kinases | OPK_II | |||||
| PAK/GCK | p21 activated kinases, Germinal center kinases | OPK-III | PAK, citron | ||||
| PAK | p21 activated kinases | OPK-III | PAK | ||||
| MAP4K | mitogen activated protein 4K | OPK-III | citron | ||||
| unknown6k | ste20 related? | OPK-III | |||||
| unknown7k | ste20 related? | OPK-III | |||||
| unknown8k | ste20 related? | OPK-III | |||||
| Tyrosine Kinases (123) | 1.0 | 0 | 8 | EGF/UFO/c-met | EGF/UFO/c-met receptor kinases | PTK-OTHER/XXI/X/XII | Ig, Fibronectin III |
| 1.1 | 7 | 50 | unknown9k | CAMK-I | |||
| RIPK | Receptor interacting PK | Ankyrin | |||||
| MAP3K/MLK | mitogen activated protein 3K, Mixed lineage kinase | OPK-XI | SH3 | ||||
| unknown10k | |||||||
| TIE | tunica interna endothelial cell kinase | PTK-XIII/XVIII | Fibronectin III, EGF like | ||||
| LIMK | lim motif containing kinases | ||||||
| RAF | RAF | OPK-VIII | PKC | ||||
| GFR | VEGFR, FGFR, PDGF | PTK-OTHER/XIV | IG various, RTKII | ||||
| 1.2 | 0 | 27 | unknown11k | SRC related | PTK-III/IV | SH2, SH3 | |
| SRC | SRC proto-onco | PTK-I | SH2, SH3 | ||||
| TEC/BTK | Bruton's tyrosine kinase | PTK-II/V | SH2, SH3, pleckstrin like, Tec/BTK | ||||
| leukocyte | PTK-XVII | RTKII | |||||
| insulin recep | insulin receptor and related kinases | PTK-XVI | RTKII, EGFR-L, furin, fibIII | ||||
| 1.3 | 3 | 28 | eph like | PTK-VIII | eph, RTK-V | ||
| eph receptors | ephrin-type a and B receptors | PTK-XI | eph, SAM, FIII, RTK-V | ||||
| JAK | Janus kinase | PTK-VII/VI | SH2, Band4.1 | ||||
| FAK | focal adhesion kinase | PTK-IX | Band4.1, focaladhesion | ||||
| 1.4 | 1 | 10 | unknown12k | PTK-XIX/XX | Ig, Frizzled, RTK-II | ||
| Other small classes | 2.0 | 1 | 13 | TGF-B recep | TGF-B, activin, BMP | OPK-IX | TGF-B R, TGF-b GS motif, Activin type II |
| 3.0 | 3 | 12 | CK1 | casein kinase 1 | OPK-XII | ||
| 4.0 | 1 | 12 | CLK | cdc-like kinase | CMGC-V | ||
| 5.0 | 2 | 8 | GC | guanylyl cyclase | GC, extracellual ligand binding recep | ||
| 6.0 | 1 | 7 | cdk4/6 | cyclin dep kin 4 and 6 | CMGC-I | ||
| 7.0 | 1 | 5 | cdc2-like | cdc2-like | CMGC-I | ||
| 8.0 | 3 | 5 | IRAK | IL-1 receptor associated | OPK-X | ||
| 9.0 | 1 | 4 | WNK | PK, lysine deficient | OPK-IV | ||
| 10 | 1 | 4 | cdk-like | cdk-like kinases | CMGC-I | ||
| 11 | 1 | 3 | GAK | cyclin G associated kinase | |||
| undefined | 16 | 76 | undefined | cluster <3 members | |||
| TOTAL | 104 | 561 |
Cluster ID refers to clusters identified by TribeMCL and CLUSTALV branches. Hanks' kinase class is provided to demonstrate overall agreement between the clustering (Hanks and Quinn 1991). Clusters labeled as unknown represent clusters in which a common underlying biology could not be identified readily for a given cluster