Table 3.
Summary of Protein Phosphatase Domain Containing Clusters Identified by TribeMCL
| Cluster ID | rik | all | branch | branch or cluster description | domain associations | |
|---|---|---|---|---|---|---|
| Tyrosine phosphatase (40) | 0.0 | 0 | 15 | recep 1 | Receptor tyrosine phosphatases—group 1 | Ig, F-III, MAM, tyro catalytic region |
| 0.1 | 1 | 5 | recep 2 | Receptor tyrosine phosphatases—group 2 | ||
| 0.2 | 1 | 7 | recep 3 | Receptor tyrosine phosphatases—group 3 | F-III, tyro catalytic region | |
| 0.3 | 0 | 7 | non-recep 1 | Non-receptor tyrosine phosphatases—group 1 | band4.1 | |
| 0.4 | 0 | 8 | non-recep 2 | Non-receptor tyrosine phosphatases—group 2 | ||
| DUSP (25) | 1.0 | 2 | 7 | DUSP | DUSP | DUSP |
| 1.1 | 3 | 13 | MKP | MAPK phosphatase | DUSP, Rhodanese like | |
| 1.2 | 0 | 5 | T-DSP | DUSP | ||
| PIP3 (9) | 2.0 | 0 | 9 | myotubularin | myotubularin PIP3 phosphatase | tyro/dusp/gram |
| Ser/Thr (9) | 3.0 | 0 | 9 | ser/thr | Ser/thr phos | Ser/thr phos, metallo-phosphoesterase |
| PP2c (9) | 4.0 | 2 | 9 | PP2c | Protein phosphatase 2c | PP2c |
| 5.0 | 0 | 5 | 4a/MPRL | phos 4a and prenylated | prenyl group binding site | |
| 6.0 | 1 | 4 | PTEN like | PTEN PIP3 phosphatase | ||
| 7.0 | 3 | 4 | cdc14 | cdc14 tyrosine phosphatases | ||
| 8.0 | 0 | 3 | sphingo | Acid Sphingomyelinase-like phosphodiesterase | Ser/thr phos, metallo-phosphoesterase | |
| 9.0 | 0 | 3 | mRNA capping | mRNA capping enzyme | Tyr phos and DUSP | |
| 10 | 0 | 3 | ser/thr 2B | ser/thr 2B phosphatase | Ser/thr phos, metallo-phosphoesterase | |
| 11 | 2 | 3 | unknown pp2c | pp2c-like | ||
| 12 | 0 | 3 | cdc25/MPI | cdc25 phosphatase/M-phase inducer phosphatase | M-phase inducer, rhodanese like | |
| undefined | 12 | 40 | undefined | clusters <3 members | ||
| TOTAL | 27 | 162 |
Cluster ID refers to clusters identified by TribeMCL and CLUSTALV branches
Cluster 11 is labeled as unknown pp2C, members contain a pp2C domain but no common underlying biology could be identified for this cluster