Figure 2.

Sliding-window analysis of K_a/K_s performed on representative functional members of human MRGX (A), murine MrgA (B), murine MrgB (C), and pseudogene members of murine MrgC (D). Protein domains are drawn schematically above each graph. Gray blocks in graphs correspond to extracellular domains. E1-E4: extracellular domains 1-4. TM1-TM7: transmembrane domains 1-7. C1-C4: cytoplasmic domains 1-4. Definitions of domain boundaries are as published (Dong et al. 2001; Lembo et al. 2002). Not all pairwise comparisons are shown due to the large number of possible pairs; data for all possible pairs are available in Supplemental Fig. S1.