Table 1.

Comparison of Strategies A and B for Fine Mapping the Location of the Disease Mutation in 100 Data Sets Simulated Based on the Cystic Fibrosis Data

LD mapping algorithm	Strategy	Mean(pos)a	Std(pos)b	Mean 95% PI widthc	RMSEd	Overlape
BLADE	A	0.8600	0.0145	0.1461	0.0262	99%
	B	0.8647	0.0315	0.1402	0.0349	96%
DHSMap	A	0.8868	0.0428	0.2141	0.0432	96%
	B	0.9072	0.0702	0.1620	0.0749	66%

^aThe average of the 100 location estimates in the 100 simulations (true location = 0.88 cM).

^bThe sample standard deviation of the 100 location estimates.

^cThe average width of the 95% probability intervals (PIs) in the 100 simulations.

^dRoot mean square error (RMSE): square root of the average squared differences between the estimated and the true location, i.e., RMSE = , where θ is the true location and is the location estimate based on the i^th simulated data set.

^eThe percentage of times (in the 100 simulations) that the 95% PI overlapped with the target region.