Table 2.

Comparison of Strategies A and B for Fine Mapping the Founder Mutation Location in 100 Simulated Data Sets With a Hypothethical Mendelian Disorder

LD mapping algorithm	Strategya	Mean(pos)b	Std(pos)c	Mean 95% PI width	RMSEd	Overlape
BLADE	A	1.9042	0.0950	0.2194	0.0947	97%
	B	1.9064	0.1367	0.1721	0.1361	93%
DHSMap	A	1.9094	0.0881	0.1059	0.0882	86%
	B	1.9097	0.1292	0.0842	0.1289	70%

^aThe average of the 100 location estimates in the 100 simulations (true location = 0.88 cM).

^bThe sample standard deviation of the 100 location estimates.

^cThe average width of the 95% probability intervals (PIs) in the 100 simulations.

^dRoot mean square error (RMSE): square root of the average squared differences between the estimated and the true location, i.e., RMSE = , where θ is the ture location and is the location estimate based on the i^th simulated data set.

^eThe percentage of times (in the 100 simulations) that the 95% PI overlapped with the target region.