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. 2003 Sep;13(9):2112–2117. doi: 10.1101/gr.586803

Table 4.

Comparison of the Fine Mapping of a Founder Mutation Using Case Haplotypes, Case Genotypes With Strategy A, and That With Strategy B for 100 Simulated Complex Disease Data Sets

Strategy #Successesa Mean(pos) Std(pos) Mean 95% PI width RMSE Size of cluster 1c
Phase known 42 0.8852 0.0940 0.3389 0.0930 19.85
A 33 0.8489 0.0818 0.3299 0.0863 20.33
Bb 41 0.9081 0.0926 0.3401 0.0957 20.41
a

The number of times that the method is successful, i.e., the 95% PI covers the true location and also has a width no greater than 25% of the whole region (1.73 cM).

b

Phased by HAPLOTYPER.

c

Average number of haplotypes being sorted into cluster 1. The total number of disease haplotypes is 50, of which 15 are the mutation-carrying haplotypes.