Table 1.

Definition and example of miR2Epi and Epi2miR pathway

Category	Definition		Example
miR2Epi regulatory pathway	miR2Epi pathway is the regulation wherein miRNA regulates epigenetic modification of Epi-Target through directly targeting Epi-Regulator.	Epi-Regulator is defined as the regulator of epigenetics.	In the discovery of Pospisil,V. et al. the miR2Epi pathway can be described as the regulatory process in which miR-29a regulates DNA methylation of FHIT and WWOX through directly targeting DNMT-3a and DNMT-3b (two important DNA methyltransferases). In this case, DNMT-3a and DNMT-3b are two Epi-Regulators, and FHIT and WWOX are corresponding to Epi-Targets. (PubMed ID: 21897363) (20)
		Epi-Target indicates molecule whose expression is controlled by epigenetics.
Epi2miR regulatory pathway	Epi2miR pathway is described as the process in which under the control of Epi-Regulator, epigenetics regulates miRNA and then affects miR-Target.	Epi-Regulator is defined as the regulator of epigenetics.	In the discovery of Yamagishi et al., the Epi2miR pathway can be described as the regulatory process wherein under the control of EZH2 and SUZ12 (two important components of polycomb repressive complex), H3K9me and H3K27me histone modification regulates miR-31 and then affects NIK. In this case, EZH2 and SUZ12 are two Epi-Regulators, and NIK is corresponding to miR-Target. (PubMed ID: 22264793)(21)
		miR-Target is the gene that is approved to be directly targeted by miRNAs.