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. 2014 May 28;9(5):e97272. doi: 10.1371/journal.pone.0097272

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© 2014 Graudenzi et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Variation of the cumulative clone density in time for the cases: simulation with , simulation with only stem cells. The relative proportion of cells belonging to each clone over the total number of cells in the crypt at each time is shown. The blue gradient is related to different classes, accounting for the ratio of alive cells belonging to each clone at the end of the simulation. The red crosses mark the clone with the largest number of members along a simulation.

Inline graphic — Variation of the cumulative clone density in time for the cases: simulation with , simulation with only stem cells. The relative proportion of cells belonging to each clone over the total number of cells in the crypt at each time is shown. The blue gradient is related to different classes, accounting for the ratio of alive cells belonging to each clone at the end of the simulation. The red crosses mark the clone with the largest number of members along a simulation.