Table 1.
| ||||||
---|---|---|---|---|---|---|
entry | Equiv 3 | Conc (M) | Solvent | Yield[a] | % Z[a] | ee (Z)[b] |
1 | 7 | 0.5 | CH2Cl2 | 35 | 83 | 93 |
2 | 7 | 0.5 | Benzene | 49 | 84 | 95 |
3 | 7 | 0.5 | Toluene | 52 | 84 | 95 |
4 | 7 | 0.5 | THF | 79 | 85 | 95 |
5 | 5 | 0.5 | THF | 71 | 84 | 96 |
6 | 3 | 0.5 | THF | 63 | 85 | 96 |
7 | 1.2 | 0.5 | THF | 29 | 87 | 97 |
8 | 7 | 0.3 | THF | 72 | 85 | 95 |
9 | 7 | 0.1 | THF | 43 | 85 | 95 |
Determined by GC.
Determined by chiral SFC.