Table 2.
| |||||
---|---|---|---|---|---|
R1 | R2 | Product | Yield[b] | %Z[c] | ee Z[d] (ee E)[d] |
TBS | OH | 7a | 66 | 88 | 99 (nd) |
H | OBz | 7b | 67 | 75 | 91 (67) |
Bz | OH | 7c | 69 | 75 | 96 (82) |
iPr | OBz | 7d | <5 | nd | nd |
0.1 mmol cyclobutene, 0.7 mmol terminal olefin.
Combined isolated yield of E and Z products.
Determined by 500 MHz 1H NMR analysis of crude reaction mixture.
Determined by chiral SFC.