Table 3.
Neurochemical changes in the SN induced by aging, 12 to 30 months (mos) and 3 days following infusion of soluble GFRα1 to the SN
Age-related changes in the SN of BNF rats (Salvatore et al. [26]) |
Impact in SN 3 days after unilateral GFRα1 infusion in SN of aged rats |
|||||
---|---|---|---|---|---|---|
Dependent Measure | 12 mos | 30 mos | % Change | Vehicle | 1 ng soluble GFRα1 | % Change |
ng DA | 7.6 | 4.9 | ↓ 36 % | 6.7 | 9.3 | ↑ 39 % |
ng TH | 0.053 | 0.028 | ↓ 47 % | 0.047 | 0.069 | ↑ 47 % |
ser31pTH | 0.10 | 0.074 | ↓ 30 % | 0.088 | 0.11 | ↑ 23 % |
Unilateral infusion of 1 ng soluble GFRα1 into the SN of aged animals increases DA per protein, TH protein expression (as ng TH per µg protein), and ser31TH phosphorylation (ser31 pTH) in the SN