Skip to main content
. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Mol Neurobiol. 2013 Jan 16;47(3):988–999. doi: 10.1007/s12035-013-8397-7

Table 3.

Neurochemical changes in the SN induced by aging, 12 to 30 months (mos) and 3 days following infusion of soluble GFRα1 to the SN

Age-related changes in the SN of BNF rats
(Salvatore et al. [26])
Impact in SN 3 days after unilateral GFRα1 infusion in SN
of aged rats


Dependent Measure 12 mos 30 mos % Change Vehicle 1 ng soluble GFRα1 % Change
ng DA 7.6 4.9 ↓ 36 % 6.7 9.3 ↑ 39 %
ng TH 0.053 0.028 ↓ 47 % 0.047 0.069 ↑ 47 %
ser31pTH 0.10 0.074 ↓ 30 % 0.088 0.11 ↑ 23 %

Unilateral infusion of 1 ng soluble GFRα1 into the SN of aged animals increases DA per protein, TH protein expression (as ng TH per µg protein), and ser31TH phosphorylation (ser31 pTH) in the SN