Table 3.
Results of HOPS and RIO for the Test Set of Putative Orthologs for H. sapiens and S. cerevisiase
| H. sapiens | S. cerevisiae | Domain | HOPS (%) | RIO (%) |
|---|---|---|---|---|
| LSM6_HUMAN | LSM6_YEAST | Sm | 0 | 1 |
| SODC_HUMAN | SODC_YEAST | sodcu | 0 | 0 |
| LSM4_HUMAN | LSM4_YEAST | Sm | 0 | 0 |
| SMD1_HUMAN | SMD1_YEAST | Sm | 0 | 0 |
| SMD2_HUMAN | SMD2_YEAST | Sm | 0.5 | 3 |
| LSM5_HUMAN | LSM5_YEAST | Sm | 1 | 0 |
| LSM3_HUMAN | LSM3_YEAST | Sm | 2.5 | 0 |
| ACBP_HUMAN | ACBP_YEAST | ACBP | 4 | 2 |
| UBCJ_HUMAN | UBC7_YEAST | UQ_con | 5 | 4 |
| RUXF_HUMAN | RUXF_YEAST | Sm | 8.5 | 0 |
| H4_HUMAN | H4_YEAST | Histone | 10 | 0 |
| FAC2_HUMAN | RCE1_YEAST | Abi | 12 | 24 |
| RPCX_HUMAN | RPCX_YEAST | DNA_RNApol_7kD | 17 | 65 |
| CAPB_HUMAN | CAPB_YEAST | F_actin_cap_B | 24 | 36 |
| CCHL_HUMAN | CCHL_YEAST | Cyto_heme_lyase | 27 | 80 |
| CDD_HUMAN | CDD_YEAST | dCMP_cyt_deam | 29.5 | 1 |
| UCR6_HUMAN | UCR7_YEAST | UCR_14kD | 31 | 56 |
| PRSA_HUMAN | PRSA_YEAST | AAA | 36.5 | — |
| RS18_HUMAN | RS18_YEAST | Ribosomal_S13 | 37 | 2 |
| NO56_HUMAN | SIK1_YEAST | Nop | 40 | 13 |
| COXG_HUMAN | COXG_YEAST | COX6B | 46.5 | 60 |
| OM20_HUMAN | OM20_YEAST | MAS20 | 47.5 | 24 |
| KIME_HUMAN | KIME_YEAST | GHMP_kinases | 50 | 24 |
| RA51_HUMAN | RA51_YEAST | HHH | 50.5 | 14 |
| NOP5_HUMAN | NOP5_YEAST | Nop | 52 | 1 |
| T2D5_HUMAN | T2D5_YEAST | TAF | 55 | 74 |
| TBCA_HUMAN | TBCA_YEAST | TBCA | 56.5 | 16 |
| SNX8_HUMAN | MVP1_YEAST | PX | 57.5 | 84 |
| CP51_HUMAN | CP51_YEAST | p450 | 59 | — |
| S61G_HUMAN | S61G_YEAST | SecE | 63 | 1 |
| GPT_HUMAN | GPT_YEAST | Glycos_transf_4 | 64.5 | 31 |
| OXA1_HUMAN | OXA1_YEAST | 60KD_IMP | 69 | 30 |
| LSM2_HUMAN | LSM2_YEAST | Sm | 71 | 2 |
| PHB_HUMAN | PHB_YEAST | Band_7 | 72.5 | 11 |
| PSB2_HUMAN | PSB2_YEAST | Proteasome | 73 | 11 |
| RPBX_HUMAN | RPBX_YEAST | RNA_pol_N | 75.5 | 23 |
| MPPA_HUMAN | MPPA_YEAST | Peptidase_M16 | 77.5 | 84 |
| IF2A_HUMAN | IF2A_YEAST | S1 | 77.5 | 49 |
| RPB9_HUMAN | RPB9_YEAST | RNA_POL_M_15KD | 78 | 96 |
| FOLC_HUMAN | FOLE_YEAST | Mur_ligase_C | 78 | 65 |
| PSA1_HUMAN | PSA1_YEAST | Proteasome | 78 | 45 |
| PRS4_HUMAN | PRS4_YEAST | AAA | 78.5 | — |
| PRI1_HUMAN | PRI1_YEAST | DNA_primase_S | 78.5 | 1 |
| DHYS_HUMAN | DHYS_YEAST | DS | 79 | 18 |
| GRE1_HUMAN | GRPE_YEAST | GrpE | 82.5 | 24 |
| FAC1_HUMAN | ST24_YEAST | Peptidase_M48 | 83 | 2 |
| ORN_HUMAN | ORN_YEAST | Exonuclease | 83 | 1 |
| HEMZ_HUMAN | HEMZ_YEAST | Ferrochelatase | 84 | 97 |
| RNHL_HUMAN | RNHL_YEAST | RNase_HII | 84 | 7 |
| PSB1_HUMAN | PSB1_YEAST | Proteasome | 85.5 | 9 |
| GCSP_HUMAN | GCSP_YEAST | GDC-P | 86 | 0 |
| PSA6_HUMAN | PSA6_YEAST | Proteasome | 86.5 | 53 |
| PSA4_HUMAN | PSA4_YEAST | Proteasome | 86.5 | 23 |
| DNL1_HUMAN | DNLI_YEAST | DNA_ligase | 86.5 | 0 |
| IF4E_HUMAN | IF4E_YEAST | IF4E | 87 | 2 |
| CY1_HUMAN | CY1_YEAST | Cytochrome_C1 | 88 | 21 |
| NTF2_HUMAN | NTF2_YEAST | NTF2 | 88.5 | 39 |
| TCPB_HUMAN | TCPB_YEAST | cpn60_TCP1 | 88.5 | 0 |
| PRS8_HUMAN | PRS8_YEAST | AAA | 89 | — |
| PSB3_HUMAN | PSB3_YEAST | Proteasome | 89 | 38 |
| T2EB_HUMAN | T2EB_YEAST | TFIIE_beta | 90 | 100 |
| VATF_HUMAN | VATF_YEAST | ATP-synt_F | 90 | 18 |
| PSA7_HUMAN | PSA7_YEAST | Proteasome | 90.5 | 20 |
| UBCH_HUMAN | UBC8_YEAST | UQ_con | 91 | 19 |
| KAD2_HUMAN | KAD1_YEAST | Adenylatekinase | 91.5 | 80 |
| MD21_HUMAN | MAD2_YEAST | HORMA | 91.5 | 7 |
| T2DB_HUMAN | T2DB_YEAST | TFIID-18 | 92 | 83 |
| RANG_HUMAN | YRB1_YEAST | Ran_BP1 | 92 | 82 |
| MSRA_HUMAN | MSRA_YEAST | PMSR | 92 | 0 |
| UFD1_HUMAN | UFD1_YEAST | UFD1 | 93 | 67 |
| KCY_HUMAN | UMPK_YEAST | Adenylatekinase | 94 | 20 |
| VA0D_HUMAN | VA0D_YEAST | vATP-synt_AC39 | 94.5 | — |
| ATPO_HUMAN | ATPO_YEAST | OSCP | 94.5 | 6 |
| RPB6_HUMAN | RPB6_YEAST | RNA_pol_Rpb6 | 94.5 | 6 |
| XPB_HUMAN | RA25_YEAST | Helicase_C | 95 | — |
| RCL1_HUMAN | RCL1_YEAST | RTC | 96.5 | 17 |
| PRS7_HUMAN | PRS7_YEAST | AAA | 97 | — |
| COXX_HUMAN | COXX_YEAST | UbiA | 97 | 45 |
| PSA3_HUMAN | PSA3_YEAST | Proteasome | 97 | 1 |
| PRS6_HUMAN | PRS6_YEAST | AAA | 98 | — |
| T2EA_HUMAN | T2EA_YEAST | 1FILE_alpha | 98 | 66 |
| TCPA_HUMAN | TCPA_YEAST | cpn60_TCP1 | 98 | 52 |
| RUXG_HUMAN | RUXG_YEAST | Sm | 98 | 41 |
| PSB4_HUMAN | PSB4_YEAST | Proteasome | 98 | 13 |
| PSA5_HUMAN | PSA5_YEAST | Proteasome | 98 | 1 |
| COPB_HUMAN | COPB_YEAST | Adaptin_N | 98.5 | 1 |
| COXA_HUMAN | COX6_YEAST | COX5A | 99 | 40 |
| TCPD_HUMAN | TCPD_YEAST | cpn60_TCP1 | 99 | 29 |
| ATPG_HUMAN | APTG_YEAST | ATP-synt | 99.5 | 96 |
| TCPH_HUMAN | TCPH_YEAST | cpn60_TCP1 | 99.5 | 20 |
| PSA2_HUMAN | PSA2_YEAST | Proteasome | 99.5 | 8 |
| TCPG_HUMAN | TCPG_YEAST | cpn60_TCP1 | 99.5 | 7 |
| T2FB_HUMAN | T2FB_YEAST | TFIIF_beta | 100 | 100 |
| BLMH_HUMAN | BLH1_YEAST | Pept_C1-like | 100 | 100 |
| PURA_HUMAN | PURA_YEAST | Adenylsucc_synt | 100 | 98 |
| XPA_HUMAN | RA14_YEAST | XPA | 100 | 80 |
| NFS1_HUMAN | NFS1_YEAST | Aminotran_5 | 100 | 68 |
| E2BA_HUMAN | E2BA_YEAST | IF-2B | 100 | 61 |
| MCM4_HUMAN | CC54_YEAST | MCM | 100 | 60 |
| MCM2_HUMAN | MCM2_YEAST | MCM | 100 | 53 |
| RPB2_HUMAN | RPB2_YEAST | RNA_pol_B | 100 | 51 |
| TCPQ_HUMAN | TCPQ_YEAST | cpn60_TCP1 | 100 | 4 |
A “—” indicates no results reported.