Table 1.

APC trial advanced adenoma susceptibility loci^*

Chromosome Region	SNP	Position (BP)	Alleles		MAF	p value	OR	Gene
2p24.2	rs11886781	18154780	A	C	0.08	9.7E-06	2.25(1.56,3.25)	KCNS3 EPHB1,
3q22.2	rs13085889	135843760	A	C	0.29	8.8E-06	1.77(1.37,2.29)	KY
3p24.1	rs1381392	28724318	A	G	0.18	7.4E-07	2.01(1.52,2.65)
3p24.1	rs17651822	28695130	A	G	0.14	2.1E-07	2.16(1.61,2.91)
7p14.3	rs17781398	30807966	A	G	0.10	9.0E-06	0.19(0.08,0.43)	FAM188b
7q32.3	rs1424593	131605541	C	A	0.50	9.1E-06	0.56 (0.44, 0.73)	PLXNA4
7q32.3	rs1364512	131602384	C	A	0.49	8.6E-06	0.56(0.42,0.71)	PLXNA4
7q32.3	rs7778725	131614936	G	A	0.49	4.0E-06	0.55(0.42,0.71)	PLXNA4
9q33.2	rs16909065	121597606	A	G	0.05	3.6E-06	2.59(1.71,3.93)
9q33.2	rs16909036	121587049	G	A	0.05	3.7E-06	2.59(1.71,3.93)
13q33.2	rs1535989	104820723	G	A	0.11	8.9E-06	2.09(1.50,2.91)
13q33.2	rs17654765	104828038	A	G	0.10	4.7E-06	2.14(1.53,2.98)
13q33.2	rs9582985	104829133	C	A	0.11	9.3E-06	2.05(1.48,2.83)
21q22.2	rs2837156	40048557	G	A	0.12	3.2E-07	2.22(1.62,3.03)	IGSF5
21q22.2	rs7278863	40087578	A	G	0.10	1.4E-08	2.48(1.80,3.42)	IGSF5
21q22.2	rs2837237	40119727	G	A	0.12	3.6E-09	2.48(1.82,3.38)
21q22.2	rs2837241	40130476	A	C	0.12	3.7E-09	2.48(1.82,3.38)
21q22.2	rs2837254	40143171	A	G	0.11	2.9E-09	2.55(1.86,3.51)
21q22.2	rs741864	40129665	A	G	0.11	1.1E-08	2.48(1.80,3.41)

^*Total number of subjects is 1,406, of which 139 developed advanced adenomas