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Loss of CYP2D6 activity as a function of the ratio of inhibitor to CYP2D6. CYP2D6 was incubated with varying concentrations of (A) paroxetine or (B) MDMA for 60 minutes to allow for complete inactivation. The partition ratio was estimated to be 70 for paroxetine and 91 for MDMA based on the intercept of the linear regression line from the lower ratios and the straight line obtained from higher ratios.
