. Author manuscript; available in PMC: 2014 May 28.

Published in final edited form as: Drug Metab Lett. 2012 Mar;6(1):7–14. doi: 10.2174/187231212800229318

Table 1.

K_I and k_inact values for inactivation of CYP2D6.

inactivator	K_I (μM)	k_inact (min⁻¹)	k_inact/K_I (ml·min⁻¹μmol⁻¹)
EMTPP¹	5.5	0.09	16
SCH66712²	0.55	0.32	582
paroxetine³	4.9	0.17	35
MDMA⁴	12.9	0.29	22

Determined with CYP2D6 Supersomes. Ref: (12).

Determined with CYP2D6 Supersomes. Ref: (9).

Determined with human liver microsomes. Ref: (10).

⁴

Determined with yeast microsomes expressing recombinant CYP2D6. Ref: (11).