. Author manuscript; available in PMC: 2014 May 28.

Published in final edited form as: Drug Metab Lett. 2012 Mar;6(1):7–14. doi: 10.2174/187231212800229318

Table 2.

Spectral Dissociation Constants for Inactivators of CYP2D6. ¹

inactivator	K_s (μM)
EMTPP	29.76 ± 3.04
SCH66712²	0.39 ± 0.10
paroxetine	0.88 ± 0.18
MDMA³	28 ± 3

All values were determined using purified, recombinant CYP2D6.

Ref: (13) ; K_s determined using the quadratic, or tight-binding equation: [CYP2D6·SCH 66712] = 0.5(K_s + E_t + S_t) − [0.25(K_s + E_t + S_t)² − E_tS_t]^1/2

Ref: (22); K_s determined using the hyperbolic curve function: ΔA = B_maxS/(K_s + S),