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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Obesity (Silver Spring). 2014 Mar 8;22(6):1512–1519. doi: 10.1002/oby.20730

Figure 1.

Figure 1

Adipose cell size, CLS presence and collagen ratio as a function of obesity.

Histological analysis of SAT adipose sections (Panel A) at 20x magnification demonstrated a significant increase in adipocyte cell area (µ2) between lean and obese participants (Panel D). CD68 immunihistochemical staining for macrophages identified CLS in 14 of 33 participants (Panel B) and a clinical increase in CLS per cm2 by obesity was observed (Panel E). Picrosirius red staining was used to assess fibrosis in SAT through obtaining a collagen ratio (Panel C). A trend in decreasing collagen ratio as a function of obesity was observed (Panel F). CLS=crown-like structures, SAT= subcutaneous adipose tissue.