Table 2.
Adipose and Liver Immunohistological Measures
| Adipose Histology | All (n=33) | Lean (n=7) | Overweight (n=16) | Obese (n=10) | |
|---|---|---|---|---|---|
| Macrophage count | 4.9 (3.6) | 4.7 (2.2) | 4.9 (4.1) | 5.1 (3.9) | |
| Macrophages per cm2 | 0.51 (0.35) | 0.78 (0.52) | 0.48 (0.25) | 0.37 (0.28) | |
| CLS (−/+) | 19/14 | 6/1 | 10/6 | 3/7 | |
| CLS per cm2 (among CLS+) | 0.06 (0.05) | 0.07 (NA) | 0.07 (0.06) | 0.05 (0.03) | |
| Adipose Cell Area (µ2) | 2267.1 (704.4) | 1924.2 (364.9) | 2148.1 (648) | 2742 (800.8) | |
| Collagen Ratio | 21.1 (14.5) | 25.1 (10.8) | 22.1 (15.6) | 16.7 (15.1) | |
| Liver Histology | Frequency (%) | ||||
| Fibrosis | 0–1 | 17 (60.6) | 5 (71.4) | 8 (50) | 7 (70) |
| 2–3 | 13 (39.4) | 2 (28.6) | 8 (50) | 3 (30) | |
| Steatosis | 0–1 | 25 (75.7) | 2 (28.6) | 3 (18.8) | 2 (20) |
| ≥2 | 8 (24.2) | 5 (71.4) | 13 (81.2) | 8 (80) | |
| Lobular Inflammation | 0–1 | 15 (44.5) | 3 (42.9) | 9 (56.2) | 3 (30) |
| 2 | 18 (54.5) | 4 (57.1) | 7 (43.8) | 7 (70) | |
| Portal Inflammation | 0–1 | 19 (57.5) | 3 (42.9) | 10 (62.5) | 6 (60) |
| 2 | 14 (42.4) | 4 (57.1) | 6 (37.5) | 4 (40) | |
| Ballooning | 0–1 | 23 (69.7) | 5 (71.4) | 12 (75) | 6 (60) |
| 2 | 10 (30.3) | 2 (28.6) | 4 (25) | 4 (40) | |
| NAS | 0–2 | 1 (3) | 1 (14.3) | 0 (0) | 0 (0) |
| 3–4 | 15 (45.5) | 2 (28.6) | 9 (56) | 4 (40) | |
| ≥5 (NASH) | 17 (51.5) | 4 (57.2) | 7 (44) | 6 (60) | |
Values are presented as means with standard deviation, unless otherwise noted. NASH=non alcoholic steatohepatitis, CLS=crown-like structure, NAS=NAFLD activity score.