Table 3.
Selected Genes Up-regulated in Bonobo Relative to Human Cells
|
H/Pd
|
H/Gd
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| LLa | Geneb | Hsac | Ppac | Ggoc | LBe | UBe | LBe | UBe | Function |
| 1396 | CRIP1 | 254 | 5129 | 1800 | -13.2 | -32.1 | -4.2 | -11.7 | Zinc carrier |
| 10521 | DDX17i | 252 | 2669 | 2825 | -7.2 | -19.1 | -7.1 | -20.8 | Putative RNA helicase |
| 2719 | GPC3f,g | 107 | 1175 | 499 | -6.1 | -16.0 | -2.6 | -6.8 | Membrane proteoglycan |
| 3191 | HNRPLh | 990 | 6218 | 3412 | -5.2 | -7.5 | -2.6 | -4.3 | RNA processing |
| 2953 | GSTT2f,i | 156 | 978 | 235 | -4.8 | -8.4 | -1.0 | -2.2 | Stress response |
| 3855 | KRT7 | 218 | 1608 | 479 | -4.7 | -11.8 | -1.2 | -3.7 | Structural |
| 9173 | IL1RL1 | 150 | 1217 | 220 | -4.2 | -12.6 | 1.3 | -2.2 | Signal transduction |
| 6000 | RGS7f | 141 | 763 | 163 | -3.8 | -7.5 | 1.1 | -1.6 | Signaling pathway |
| 5157 | PDGFRLg | 150 | 860 | 514 | -3.6 | -8.8 | -1.7 | -5.7 | Signaling pathway |
| 7784 | ZP3Af,g | 150 | 654 | 109 | -3.4 | -5.8 | 1.0 | 1.8 | Extracellular matrix |
| 51632 | NCUBE1i | 159 | 633 | 675 | -3.3 | -4.7 | -3.5 | -5.1 | Ubiquitin-related |
| 8710 | SERPINB7 | 129 | 665 | 428 | -3.1 | -7.5 | -2.0 | -4.8 | Protease inhibitor |
| 868 | CBLB | 316 | 1453 | 389 | -3.0 | -6.4 | 1.1 | -1.7 | Signal transduction |
| 5055 | SERPINB2 | 2113 | 9784 | 7863 | -3.0 | -8.3 | -2.5 | -6.6 | Protease inhibitor |
| 10397 | NDRG1 | 1431 | 5198 | 834 | -3.0 | -4.4 | 1.4 | 2.2 | Signal tranduction |
| 1746 | DLX2 | 128 | 513 | 146 | -2.8 | -5.4 | 1.3 | -1.5 | Transcription factor |
| 1022 | CDK7 | 289 | 1021 | 479 | -2.7 | -4.7 | -1.2 | -2.3 | Cell cycle |
| 27063 | CARP | 119 | 561 | 171 | -2.6 | -7.0 | 1.3 | -2.1 | DNA-binding protein |
| 6272 | SORT1g | 109 | 360 | 283 | -2.5 | -4.1 | -2.2 | -3.1 | Golgi transmembrane |
| 1012 | CDH13 | 405 | 1477 | 948 | -2.5 | -5.3 | -1.7 | -3.4 | Cell-cell interactions |
| 154 | ADRB2 | 130 | 425 | 117 | -2.5 | -4.1 | -1.1 | 1.4 | Signal transduction |
| 10413 | YAP1h | 165 | 525 | 593 | -2.5 | -4.0 | -2.9 | -4.5 | WW domain protein |
Genes show a lower bound of 95% confidence interval of greater than or equal to 2.5-fold change
Donor species [(Hsa) Homo sapiens, (Ppa) Pan pansicus, (Ggo) Gorilla gorilla] along with gene expression score
95% confidence interval of ratios of Hsa/Ppa or Hsa/Ggo gene expression levels
Lower (LB) and upper (UB) bounds of 95% confidence interval
Confirmed by Northern blot analysis
Greater than or equal to 2.0-fold up-regulated in chimpanzee brain relative to human brain (Enard et al. 2002a)
Greater than or equal to 2.0-fold up-regulated in chimpanzee liver relative to human liver (Enard et al. 2002a)
Greater than or equal to 2.0-fold up-regulated in chimpanzee brain and liver relative to human brain and liver (Enard et al. 2002a)