Table 3.
Relationship between gene expression and exacerbations
| Gene | Categorical | Quantitative (Peak Asthma Index) | |||
|---|---|---|---|---|---|
| No exacerbation (Index 0–29) | Exacerbation (Index ≥ 30) | P‐value | Correlation | P‐value | |
| IFN‐γ | 1.73 (1.45–2.09) | 2.47 (2.02–2.88) | 0.002 | 0.51 | 0.004 |
| IFN‐λ1 (IL‐29) | 3.16 (2.53–3.93) | 4.16 (2.92–4.92) | 0.36 | 0.30 | 0.11 |
| IFN‐α1 | 1.66 (1.57–1.91) | 2.02 (1.75–2.56) | 0.06 | 0.58 | <0.001 |
| IFN‐β1 | 1.52 (1.43–1.83) | 2.05 (1.60–2.56) | 0.06 | 0.57 | 0.001 |
| IL‐10 | 1.83 (1.27–2.47) | 2.30 (1.93–2.61) | 0.06 | 0.28 | 0.13 |
| MBP | 1.67 (1.43–1.82) | 2.26 (1.77–2.67) | 0.02 | 0.32 | 0.08 |
| IL‐13 | 1.66 (1.18–2.45) | 2.36 (1.85–2.86) | 0.03 | 0.49 | 0.006 |
| Neutrophil Elastase | 2.37 (1.81–2.75) | 2.75 (2.09–3.29) | 0.11 | 0.32 | 0.08 |
The quantification of gene expression was compared categorically between the subjects with no exacerbation vs. those with exacerbation, based on the Asthma Index. The mRNA quantification (normalized and log‐transformed) and P‐value for the comparison are shown. Data are shown as medians with interquartile range. The quantification of gene expression (normalized and log‐transformed) was also analysed by linear regression with the Peak Asthma Index as a continuous variable. The correlation coefficient and P‐value are shown.
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