A. mRNA levels of indicated genes in SMCs isolated from aortas of HFHSD- or ND-fed mice and cultured in 0.2% FBS DMEM overnight. *p < 0.05 vs. ND, n=5. B. Representative Western blots of homogenates of aortic SMCs isolated from HFHSD- or ND-fed mice and cultured in 0.2% FBS DMEM overnight. Nox2 (58 kDa), Rac1 (21 kDa), Nox4 (66 kDa), SERCA and SERCA C674-SO3H (110 kDa), p65NFκB and p-p65NFκB (65 kDa), VCAM1 (100 kDa), TNFα (17 kDa), GAPDH (36 kDa). Quantitation of band intensities in graph. *p < 0.05 vs. ND, n=3–10.