Table 2.
HDL QTLs in Female Mice From (C57BL/6J×NZB)×C57BL/6J Backcross and C57BL/6J×NZB/BINJ AIL
| Cross | Phenotype | Chr | cM | 95% CI (cM)a | Nearest marker | LODb | % variance explainedc | Locus name | Homologous human QTL |
|---|---|---|---|---|---|---|---|---|---|
| Backcross | 0 w HDL | 1 | 96 | 84-100 | D1Mit206 | 5.5 | 22.3% | Hdlq5 | |
| 5 | 54 | 40-60 | D5Mit10 | 2.1 | 9.0% | ||||
| 4 w HDL | 1 | 102 | 87-110 | D1Mit291 | 5.8 | 23.3% | Hdlq6 | ||
| 5 | 38 | 34-42 | D5Mit200 | 4.7 | 19.2% | ||||
| AIL | 0 w HDL | 1 | 91 | 87-93 | D1Mit15 | 37.0 | 39.0% | Hdlq5 | 1q21-23,d 1q23-25e |
| 5 | 29 | 25-32 | D5Mit233 | 12.0 | 14.8% | Hdlq7 | 4p16-15.3e | ||
| 5 | 69 | 66-70 | D5Mit242 | 7.1 | 9.0% | Hdlq1 | 12q24.2,g, 13q12-13d,f | ||
| 16 | 59 | 50-60 | D16Mit227 | 1.3 | 0.9% | Hdlq9 | |||
| 6 w HDL | 1 | 89 | 87-93 | D1Mit15 | 13.6 | 16.6% | Hdlq5 | 1q21-23,d 1q23-25e | |
| 1 | 100 | 98-102 | D1Mit166 | 11.4 | 14.1% | Hdlq6 | |||
| 5 | 29 | 26-32 | D5Mit233 | 7.8 | 9.9% | Hdlq7 | 4p16-15.3e | ||
| 5 | 60 | 58-63 | D5Mit155 | 3.6 | 4.7% | Hdlq8 | 1p22f | ||
| 5 | 69 | 66-77 | D5Mit371 | 5.8 | 7.4% | Hdlq1 | 12q24.2,g 13q12-13d,f |
a
Confidence interval (CI) was calculated according to the posterior probability densities of the QTL locations
b
Significant thresholds of LOD score were determined by permutation tests. In the backcross, the threshold of suggestive LOD score is 2.0, significant one is 2.3; in AIL, the threshold of suggestive LOD score is 2.5, significant one is 3.0
c
Phenotypic variance explained by each QTL is based on a single-QTL model