Table 3.
Statistical Test for the Existence of Multiple QTLs on the Same Chromosome
|
Chr 1
|
Chr 5
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| HDL QTL | LOD1 | LOD2 | ΔLOD2-1 | HDL QTL | LOD1 | LOD2 | LOD3 | ΔLOD2-1 | ΔLOD3-2 | |
| Chow | Hdlq5 | — | — | — | Hdlq7, Hdlq1 | 10.3 | 12.5 | — | 2.2 | — |
| High fat | Hdlq5, Hdlq6 | 13.4 | 14.9 | 1.5 | Hdlq7, Hdlq8, Hdlq1 | 7.0 | 9.4 | 11.3 | 2.4 | 1.9 |
HDL QTL refers to the significant QTLs found in single-QTL model. LOD1, LOD2, and LOD3 are LOD scores for one-QTL, two-QTL, and three-QTL models, respectively. ΔLOD2-1 = LOD2 - LOD1; ΔLOD3-2 = LOD3 - LOD2
Threshold LOD differences were computed by permutation tests: ΔLOD = 1.99 (P = 0.05), ΔLOD = 1.83 (P = 0.10), and ΔLOD = 1.58 (P = 0.20)