Table 4.
Multiple Regression Model for Loci Affecting Plasma HDL Concentrations in Female Mice From C57BL/6J×NZB AIL
| Diet | Chr | cM | Source (locus) | df | Adjusted SS | % variance explained | F | P |
|---|---|---|---|---|---|---|---|---|
| Chow | 1 | 91 | Hdlq5 | 2 | 4.24 | 28.7 | 92.75 | 2.0 × 10-16 |
| 5 | 29 | Hdlq7 | 2 | 0.32 | 6.8 | 7.09 | 7.0 × 10-4 | |
| 5 | 69 | Hdlq1 | 2 | 0.48 | 10.61 | 3.4 × 10-5 | ||
| 16 | 59 | Hdlq9 | 2 | 0.17 | 1.2 | 3.80 | 0.023 | |
| Error | 333 | |||||||
| Total | 341 | |||||||
| High fat | 1 | 89 | Hdlq5 | 2 | 0.40 | 14.1 | 4.69 | 1.0 × 10-3 |
| 1 | 100 | Hdlq6 | 2 | 0.21 | 2.42 | 0.090 | ||
| 5 | 29 | Hdlq7 | 2 | 0.43 | 9.0 | 5.00 | 7.2 × 10-3 | |
| 5 | 60 | Hdlq8 | 2 | 0.33 | 3.82 | 0.023 | ||
| 5 | 69 | Hdlq1 | 2 | 0.26 | 3.03 | 0.049 | ||
| Error | 334 | |||||||
| Total | 344 |
P values are based on the F distribution with 2 and 333 degrees of freedom (df) in chow diet mice and with 2 and 334 degrees of df in high fat-fed mice. F statistics from the multiple regression model are based on adjusted sums of squares