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. Author manuscript; available in PMC: 2015 Sep 15.
Published in final edited form as: Eur J Pharmacol. 2013 Nov 28;0:74–82. doi: 10.1016/j.ejphar.2013.10.070

Figure 1. The AHP and intracellular Ca2+ are altered by aging.

Figure 1

A: Example of the sAHP in hippocampal neurons from a young and an aging rat, showing the increased AHP magnitude with aging (darker trace); also shown are examples of the increase in intracellular Ca2+ transients (inset). Age-related increases in sAHP amplitude (B) and Ca2+ transients (C) begin by 12 months-of-age and are blocked by ryanodine, indicating the increases depend on CICR from RyRs (* p < .05). (From Gant et al., 2006)