Table 2.
Polymorphisms in pfdhfr, pfdhps and pfmdr1 genes in clinical samples and after culture adaptation for 28 days.
| Sample | dhfr | dhps | mdr1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N51I | I164 L | S436A | A581G | N86Y | Y184F | S1034C | N1042D | |||||||||
| D0 | D28 | D0 | D28 | D0 | D28 | D0 | D28 | D0 | D28 | D0 | D28 | D0 | D28 | D0 | D28 | |
| N77 | N | N | L | L | S | S | A | A | N | N | F | F | S | S | N | N |
| N36 | N | N | L | L | S | S | A/G | A | N | N | F | F | S | S | N | N |
| A45 | N | N | L | L | S | S | A | A | N | N | F | F | S | S | N | N |
| A28 | N | N | L | L | S | S | A | A | N | N | F | F | S | S | N | N |
| A34 | N | N | L | L | S | S | A | A | N | N | F | F | S | S | N | N |
| A16 | N | N | L | L | S | S | A/G | A/G | N | N | F | F | S | S | N | N |
| A32 | N | N | L | L | S | S | A | A | N | N | F | F | S | S | N | N |
| A12 | N | N | L | L | S | S | A/G | A/G | N | N | F | F | S | S | N | N |
| N17 | N | N | L | L | S | S | A | A | N | N | F | F | S | S | D | D |
| A57 | N | N | L | L | S | S | A | A | N | N | F | F | S | S | N | N |
| N13 | N | N | L | L | S | S | A | A | N | N | F | F | S | S | N | N |
| A50 | N | N | L | L | S | S | A | A | N | N | F | F | S | S | N | N |
| A39 | N | N | L | L | S | S | G | G | N | N | F | F | S | S | N | N |
| A5 | N | N | L | L | S | S | A | A | N | N | F | F | S | S | N | N |
| A52 | N | N | L | L | S | S | A | A | N | N | F | F | S | S | N | N |
Note: Samples highlighted in bold had become monoclonal by day 28 based on genotyping of msp1 block 2.