Table 1.
Genes Included in the ImmunoQuantArray
| Gene | GenBank accession # | Name | ||
|---|---|---|---|---|
| Aopoptosis/antiapoptosis | ||||
| Bad | NM_007522 | Bcl-associated death promoter | ||
| Bax | NM_007527 | Bcl2-associated X protein | ||
| Bcl2 | NM_009741 | B-cell leukemia/lymphoma 2 | ||
| Bcl21 | NM_009743 | Bcl2-like [Bcl-x] | ||
| Bid | U75506 | BH3-interacting domain death agonist | ||
| Fadd | NM_010175 | Fas-associated via death domain | ||
| Cflar | U97076 | CASP8 AND FADD-like apoptosis regulator [FLIP(L)] domain death agonist | ||
| Tnfrsf6 | NM_007987 | Tumor necrosis factor receptor superfamily, member 6 [Fas] | ||
| Tnfsf6 | NM_010177 | Tumor necrosis factor (ligand) superfamily, member 6 [FasL] | ||
| Pfp | M23182 | Pore-forming protein [perforin] | ||
| Costimulatory/activation cell curface ligands | ||||
| Cd28 | NM_007642 | CD28 antigen | ||
| Cd44 | M27130 | CD44 antigen | ||
| Cd80 | AF065894 | CD80 antigen | ||
| Cd86 | NM_019388 | CD86 antigen | ||
| Icosl | AF216747 | ICOS-ligand | ||
| Mox2 | AF231126 | Antigen identified by monoclonal antibody MRC OX-2 | ||
| Leukocyte cell surface differentiation markers | ||||
| Cd4 | NM_013488 | CD4 antigen | ||
| Cd5 | NM_007650 | CD5 antigen | ||
| Cd34 | S69293 | CD34 antigen | ||
| Cd3e | M23376 | CD3 antigen, epsilon polypeptide | ||
| Cd8a | AJ131778 | CD8 antigen, α-chain | ||
| Cd8b | NM_009858 | CD8 antigen, β-chain | ||
| Ptprc | NM_011210 | Protein tyrosine phosphatase, receptor type, C | ||
| Art2b | AF016465 | ADP-ribosyltransferase 2b | ||
| Fc receptors | ||||
| Fcer1a | NM_010184 | Fc receptor, IgE, high affinity I, α polypeptide | ||
| Fcer1g | NM_010185 | Fc receptor, IgE, high affinity I, γ polypeptide | ||
| Fcgrt | NM_010189 | Fc receptor, IgG, α chain transporter | ||
| Cytokines | ||||
| Il1b | NM_008361 | Interleukin 1 β | ||
| Il2 | NM_008366 | Interleukin 2 | ||
| Il4 | NM_021283 | Interleukin 4 | ||
| Il5 | NM_010558 | Interleukin 5 | ||
| Il6 | M20572 | Interleukin 6 | ||
| Il7 | NM_008371 | Interleukin 7 | ||
| Il10 | NM_010548 | Interleukin 10 | ||
| Il12a | NM_008351 | Interleukin-12 [p35 subunit] | ||
| Il12b | NM_008352 | Interleukin-12 [p40 subunit] | ||
| Il15 | NM_008357 | Interleukin 15 | ||
| Il18 | NM_008360 | Interleukin 18 | ||
| Csf1 | NM_007778 | Colony-stimulating factor 1 (macrophage) | ||
| Csf3 | NM_009971 | Colony-stimulating factor 3 (granulocyte) | ||
| Tgfb1 | AJ009862 | Transforming growth factor, β 1 | ||
| Lta | NM_010735 | Lymphotoxin A | ||
| Ltb | NM_008518 | Lymphotoxin B | ||
| Ifna1 | NM_010502 | Interferon α family, gene 1 | ||
| Ifnb | NM_010510 | Interferon β, fibroblast | ||
| Ifng | K00083 | Interferon γ | ||
| Tnf | X02611 | Tumor necrosis factor | ||
| Tnfsf11 | AF013170 | Tumor necrosis factor (ligand) superfamily, member 11 | ||
| Tnfrsf1a | NM_011609 | Tumor necrosis factor receptor superfamily, member 1a | ||
| Tnfrsf1b | NM_011610 | Tumor necrosis factor receptor superfamily, member 1b | ||
| Tnfrsf11b | NM_008764 | Tumor necrosis factor receptor superfamily, member 11b [osteoprotegerin] | ||
| Cytokine receptors | ||||
| Il1r1 | NM_008362 | Interleukin 1 receptor, type I | ||
| Il2ra | NM_008367 | Interleukin 2 receptor, α chain | ||
| Il2rg | NM_013563 | Interleukin 2 receptor, γ chain | ||
| Il4ra | NM_010557 | Interleukin 4 receptor, α | ||
| Il7r | NM_008372 | Interleukin 7 receptor | ||
| Il10ra | NM_008348 | Interleukin 10 receptor, α | ||
| Il12rb2 | NM_008354 | Interleukin 12 receptor, β 2 | ||
| Ltbr | NM_010736 | Lymphotoxin B receptor | ||
| Ifngr2 | NM_008338 | Interferon γ receptor 2 | ||
| Leukocyte adhesion | ||||
| Sell | NM_011346 | Selectin, lymphocyte | ||
| Itgal | AF065901 | Integrin α L | ||
| Itgam | NM_008401 | Integrin α M | ||
| Itgax | NM_021334 | Integrin α X | ||
| Innate immune cell surface receptor/ligands | ||||
| Tlr2 | AF165189 | Toll-like receptor 2 | ||
| Tlr4 | AF185285 | Toll-like receptor 4 | ||
| Klrb1d | AF338322 | Killer cell lectin-like receptor subfamily B member 1D | ||
| Cd1d1 | M63695 | CD1d1 antigen | ||
| Immune activation/signal transduction | ||||
| Zap70 | NM_009539 | ζ-chain (TCR) associated protein kinase (70 kD) | ||
| Cd3z | U17267 | T cell receptor-ζ chain | ||
| Il1rak | NM_008363 | Interleukin 1 receptor-associated kinase | ||
| C2ta | NM_007575 | Class II transactivator | ||
| Btk | NM_013482 | Bruton agammaglobulinemia tyrosine kinase | ||
| Jun | NM_010591 | Jun oncogene | ||
| Fyn | NM_008054 | Fyn proto-oncogene | ||
| Lck | M12056 | Lymphocyte protein tyrosine kinase | ||
| Map2k1 | NM_008927 | Mitogen-activated protein kinase 1 [MEK1] | ||
| Map2k2 | NM_023138 | Mitogen-activated protein kinase 2 [MEK2] | ||
| Nfkb1 | NM_008689 | Nuclear factor of κ light chain enhancer in B-cells 1, p105 | ||
| Hcph | NM_013545 | Hemopoietic cell phosphatase | ||
| Myd88 | NM_010851 | Myeloid differentiation primary response gene 88 | ||
| Csk | NM_007783 | C-src tyrosine kinase | ||
| Chemokines and chemokine receptors | ||||
| Scyc1 | U15607 | Small inducible cytokine subfamily C, member [lymphotactin] | ||
| Lcp2 | NM_010696 | Lymphocyte cytosolic protein 2 | ||
| Scya19 | Af307988 | Small inducible cytokine A19 | ||
| Scya20 | NM 016960 | Small inducible cytokine subfamily A20 | ||
| Scyd1 | NM_009142 | Small inducible cytokine subfamily D, 1 | ||
| Ccxcr1 | NM_011798 | Chemokine (C motif) XC receptor 1 | ||
| Stress response | ||||
| Tra1 | NM_011631 | Tumor rejection antigen gp96 | ||
| Hsp70-2 | NM_008301 | Heat shock protein, 70 kDa 2 | ||
| Hsp70-1 | M35021 | Heat shock protein, 70 kDa 1 | ||
| Other | ||||
| Rn18s | X00686 | 18S RNA [ribosomal] | ||
| Hprt | NM_013556 | Hypoxanthine guanine phosphoribosyl transferase | ||
| Gapd | NM_008084 | Glyceraldehyde-3-phosphate dehydrogenase | ||
| Tbp | NM_013684 | TATA-box-binding protein | ||
| Zfp106 | AF060246 | Zinc finger protein 106 | ||
| Rag1 | NM_009019 | Recombination activating gene 1 | ||
| Terc | AF047387 | Telomerase RNA component | ||
| Tert | NM_009354 | Telomerase reverse transcriptase | ||
| Nos2 | NM_010927 | Nitric oxide synthase 2, inducible, macrophage | ||
Primer sequences available in Supplemental Material; available online at http://www.genome.org