Fig. 2.

Release profile of DOX from HAuNS complexes when irradiated with an 808-nm NIR laser. a Ultraviolet-visible spectra of DOX@HAuNS before and after NIR laser irradiation. Inset photograph of aqueous solutions of a DOX@HAuNS before laser irradiation, b released DOX collected in the supernatant, and c DOX@HAuNS after complete release of DOX. b Release of DOX from DOX@HAuNS (blue line) and DOX@AuNP (pink line) under repeated NIR laser exposure. c NIR light-triggered release of DOX from DOX@HAuNS and DOX@PEG-HAuNS with and without NIR laser irradiation. Rapid DOX release was observed during NIR exposure (5 min, red lines), and the release was turned off when the laser was switched off. d DOX payload was higher in HAuNS than in solid AuNS. Reproduced with permission from ref. (18). Copyright 2010, ACS