Table II.
Ketoprofen Pediatric Dose Number for Various Pediatric Subpopulations
| Dose formula | Neonates (0–1 months) |
Infant (1–24 months) |
Children (2–12 years) |
Adolescents (12–16 years) |
|---|---|---|---|---|
| Young’s Rulea | 0.0415 | 0.494 | 1.20 | 1.02 |
| Clark’s Ruleb | 0.703 | 0.948 | 1.10 | 1.41 |
| Modified Weight Rulec | 0.960 | 1.29 | 1.50 | 1.93 |
| Body surface aread | 1.67 | 1.67 | 1.67 | 1.67 |
In calculating pediatric dose for each subpopulation and from each dose formula, the adult dose was taken to be 75 mg. Age was taken to be the mid-point of the subpopulation age (i.e., 0.5 months, 12.5 months, 7 years, and 14 years for neonates, infants, children, and adolescents, respectively). Conversion from dose to dose number employed a BSA-derived volume of 34.7, 67.4, 127.6, and 220.3 ml for neonates, infants, children, and adolescents, respectively. BSA employed height and weight, which were taken to be the 50 percentile of boy values in the CDC growth charts for ages 0.5 months, 12.5 months, 7 years, and 14 years for neonates, infants, children, and adolescents, respectively (17,18). Drug solubility was taken to be 0.180 mg/ml (14). Ketoprofen is not indicated for use in the pediatric population (24)
aYoung’s Rule employs age, which was taken to be the mid-point of the subpopulation age (i.e., 0.5 months, 12.5 months, 7 years, and 14 years for neonates, infants, children, and adolescents, respectively) (17,18). From Young’s Rule, the dose was calculated to be 0.260, 5.99, 27.6, and 40.4 mg for neonates, infants, children, and adolescents, respectively
bClark’s Rule employs weight, which was taken to be the 50 percentile of boy values in the CDC growth charts for ages neonates, infants, children, and adolescents (17,18). From Clark’s Rule, the dose was calculated to be 4.40, 11.5, 25.3, and 56.1 mg for neonates, infants, children, and adolescents, respectively
cModified Weight Rule employs weight, which was taken to be the 50 percentile of boy values in the CDC growth charts for ages neonates, infants, children, and adolescents (17,18). From Modified Weight Rule, the dose was calculated to be 6.00, 15.7, 34.5, and 76.5 mg for neonates, infants, children, and adolescents, respectively
dBody surface area employs height and weight, which were taken to be the 50 percentile of boy values in the CDC growth charts for ages neonates, infants, children, and adolescents (17,18). From body surface area, the dose was calculated to be 10.4, 20.2, 38.3, and 66.1 mg for neonates, infants, children, and adolescents, respectively