Table III.

Calculation of Ketoprofen Dose Number for Individual Patients Reported in Kokki et al. (10)

Subject	Age (month)	Weight (kg)	Height (cm)	BSA-derived volume (ml)	Dose (mg)	Dose number
11	16	12	84	76.5	12.5	0.907
12	52	17	100	99.3	12.6	0.704
13	22	15	89	88.0	12.5	0.786
14	35	15	95	90.9	12.5	0.761
15	61	20	111	113.5	25.0	1.22
16	54	19	110	110	25.1	1.27
17	59	23	115	124	25.1	1.12
18	25	12	88	78.3	12.5	0.886
19	69	17	111	104	12.6	0.668
20	69	18	114	109	25.0	1.27

Subject age, weight, height and dose were obtained from the article to calculate BSA-derived pediatric reference volume. Dose numbers for each infant and child reflected high solubility when dose was low (i.e., 12 mg) and low solubility when the dose was high (i.e., 25 mg). Dose number values here were approximately one, in agreement with the general approach (Table II)