Table 2. Mean histological scoring of lungs from comorbidity models and controls.
| (A) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Parameter |
AA model |
|||||||||
| AA+Flu | Flu ctr | |||||||||
| Days after pH1N1 | 1 | 3 | 5 | 7 | 9 | 1 | 3 | 5 | 7 | 9 |
| PB inflammation | + | + | +++(+) | +++ | ++(+) | − | + | + | +++ | ++ |
| PV inflammation | ++(+) | +++ | +++ | ++(+) | ++(+) | − | + | + | +++ | ++(+) |
| Epi. hyperplasia | − | − | − | − | − | − | + | + | ++ | ++ |
| Epi. necrosis | − | − | − | − | − | − | ++ | ++ | ++ | − |
| (B) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Parameter |
CA model |
|||||||||
| CA+Flu | Flu ctr | |||||||||
| Days after pH1N1 | 1 | 3 | 5 | 7 | 9 | 1 | 3 | 5 | 7 | 9 |
| PB inflammation | + | ++ | ++ | +++ | +++ | − | (+) | + | +(+) | ++ |
| PV inflammation | +(+) | ++ | ++ | +++ | +++ | (+) | + | +(+) | ++ | ++ |
| Epi. hyperplasia | − | + | + | ++ | ++ | − | − | + | +(+) | + |
| Epi. necrosis | − | − | − | − | − | − | − | (+) | (+) | − |
Abbreviations: AA, acute asthma; CA, chronic asthma; ctr, controls; Epi, epithelial; Flu, influenza; PB, peribronchial; PV, perivascular.
Mean staining intensity score for analyzed parameters from 0 to 4, where ‘−' indicates 0 and (+) indicates a half-point.