Table 3. Observed genotype frequencies for studied SNPs among T2DM cases.
| SNP and genotype | Controls, no., (%) | T2DM, no., (%) | OR | 95% CI | p- value |
|---|---|---|---|---|---|
|
rs4986790 (TLR4_Asp299Gly) 119515123 | |||||
| AA |
247 (77.2) |
287 (76.0) |
– |
– |
– |
| AG |
73 (22.8) |
89 (23.5) |
1.01 |
0.71 to 1.44 |
0.93 |
| GG |
0 (0) |
2 (0.5) |
6.2 |
0.38 to 101.4 |
0.19 |
| AG + GG |
73 (22.8) |
91 (24.1) |
1.01 |
0.71 to 1.44 |
0.84 |
|
rs4986791 (TLR4_Thr399Ile) 119515423 | |||||
| CC |
262 (81.9) |
302 (79.9) |
– |
– |
– |
| CT |
54 (16.9) |
73 (19.3) |
1.17 |
0.79 to 1.72 |
0.42 |
| TT |
4 (1.2) |
3 (0.8) |
0.65 |
0.14 to 2.89 |
0.57 |
| CT + TT |
58 (18.1) |
76 (20.1) |
1.13 |
0.77 to 1.65 |
0.35 |
|
rs10759931 (TLR4_1859) 120464147 | |||||
| AA |
173 (54.1) |
183 (48.4) |
– |
– |
– |
| AG |
144 (45.0) |
194 (51.3) |
1.26 |
0.93 to 1.70 |
0.12 |
| GG |
3 (0.9) |
1 (0.3) |
0.34 |
0.04 to 2.48 |
0.29 |
| AG + GG |
147 (46.0) |
195 (51.6) |
1.25 |
0.92 to 1.67 |
0.14 |
|
rs1927914 (TLR4_2437) 120464725 | |||||
| TT |
184 (57.5) |
181 (47.9) |
– |
– |
– |
| TC |
134 (41.9) |
181 (47.9) |
1.37 |
1.01 to 1.85 |
0.04 |
| CC |
2 (0.6) |
16 (4.2) |
4.8 |
1.86 to 12.36 |
0.001 |
| TC + CC |
136 (42.5) |
197 (52.1) |
1.46 |
1.09 to 1.97 |
0.001 |
|
rs1927911 (TLR4_7764) 120470054 | |||||
| CC |
112 (35.0) |
177 (46.8) |
– |
– |
– |
| CT |
164 (51.2) |
169 (44.7) |
0.65 |
0.47 to 0.89 |
0.008 |
| TT |
44 (13.8) |
32 (8.5) |
0.45 |
0.27 to 0.76 |
0.002 |
| CT + TT | 212 (66.3) | 201 (53.2) | 0.6 | 0.44 to 0.81 | 0.001 |
Genotype frequencies of single nucleotide polymorphisms (SNPs) rs4986790, rs4986791, rs10759931, rs1927911 and rs1927914 of TLR4 gene among T2DM and controls