Table 4. Observed Genotype frequencies for studied SNPs among DR cases.
| SNP and genotype | Controls, no., (%) | DR, no., (%) | OR | 95% CI | p- value |
|---|---|---|---|---|---|
|
rs4986790 (TLR4_Asp299Gly) 119515123 | |||||
| AA |
247 (77.2) |
99 (77.4) |
– |
– |
– |
| AG |
73 (22.8) |
28 (21.8) |
0.95 |
0.58 to 1.56 |
0.86 |
| GG |
0 (0) |
1 (0.8) |
– |
– |
– |
| AG + GG |
73 (22.8) |
29 (22.7) |
0.99 |
0.61 to 1.61 |
0.97 |
|
rs4986791 (TLR4_Thr399Ile) 119515423 | |||||
| CC |
262 (81.9) |
102 (79.7) |
– |
– |
– |
| CT |
54 (16.9) |
26 (20.3) |
1.24 |
0.72 to 2.12 |
0.42 |
| TT |
4 (1.2) |
0 (0) |
0.24 |
0.02 to 2.23 |
0.21 |
| CT + TT |
58 (18.1) |
26 (20.3) |
1.15 |
0.68 to 1.95 |
0.59 |
|
rs10759931 (TLR4_1859) 120464147 | |||||
| AA |
173 (54.1) |
56 (43.7) |
– |
– |
– |
| AG |
144 (45.0) |
72 (56.3) |
1.53 |
1.01 to 2.31 |
0.04 |
| GG |
3 (0.9) |
0 (0) |
0.26 |
0.02 to 3.74 |
0.32 |
| AG + GG |
147 (46.0) |
72 (56.3) |
1.5 |
0.99 to 2.26 |
0.05 |
|
rs1927914 (TLR4_2437) 120464725 | |||||
| TT |
184 (57.5) |
61 (47.7) |
– |
– |
– |
| TC |
134 (41.9) |
66 (51.5) |
1.48 |
1.00 to 2.25 |
0.05 |
| CC |
2 (0.6) |
1 (0.8) |
1.56 |
0.11 to 21.58 |
0.73 |
| TC + CC |
136 (42.5) |
67 (52.3) |
1.48 |
1.00 to 2.24 |
0.05 |
|
rs1927911 (TLR4_7764) 120470054 |
|||||
| CC |
112 (35.0) |
52 (40.6) |
– |
– |
– |
| CT |
164 (51.2) |
66 (51.5) |
0.86 |
0.55 to 1.34 |
0.51 |
| TT |
44 (13.8) |
10 (7.8) |
0.52 |
0.26 to 1.03 |
0.06 |
| CT + TT | 212 (66.3) | 76 (59.4) | 0.77 | 0.50 to 1.17 | 0.22 |
Genotype frequencies of single nucleotide polymorphisms (SNPs) rs4986790, rs4986791, rs10759931, rs1927911 and rs1927914 of TLR4 gene among DR and controls.