Figure 3.

Influence of stochastic gene expression on system behavior. (A) Deterministic and stochastic time courses for transcript MAduring a step of ligand. The deterministic simulation does not show adaptation (solid line), whereas some (circles) but not all stochastic simulations (stars) do. (B) Variance in transcript levels (σ²_Mi) vs. time for MA, MB, and MC. Despite constant ligand input, the variance increases for these transcripts at later times due to the transient adaptation of an increasing fraction of the population.