Table 2.
Fractions of Consistent Transcription Factor Target Genes in the Yeast Regulatory Network Classified by the Functional Class of the Target
MRM
|
TM
|
Number of regulators
|
|||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Functional class | n | P < 0.01 | P < 0.005 | P < 0.001 | n | P < 0.01 | P < 0.005 | P < 0.001 | 1 | 2 | 3 | 4 | >4 |
Pheromone response | 10 | 0.4 | 0.4 | 0.3 | 30 | 0.37 | 0.27 | 0.13 | 6 | 8 | 5 | 3 | 8 |
Detoxification | 16 | 0.38 | 0.38 | 0.31 | 27 | 0.33 | 0.22 | 0.07 | 11 | 10 | 4 | 0 | 2 |
Nucleotide metabolism | 21 | 0.33 | 0.24 | 0.19 | 25 | 0.28 | 0.2 | 0.2 | 3 | 16 | 3 | 3 | 0 |
DNA synthesis and replication | 11 | 0.27 | 0.27 | 0.18 | 18 | 0.17 | 0.06 | 0 | 8 | 6 | 2 | 1 | 1 |
Amino acid metabolism | 35 | 0.26 | 0.2 | 0.11 | 61 | 0.39 | 0.33 | 0.18 | 23 | 14 | 16 | 5 | 3 |
Carbohydrate metabolism | 50 | 0.26 | 0.18 | 0.12 | 83 | 0.2 | 0.13 | 0.06 | 26 | 22 | 20 | 3 | 12 |
Mitotic cell cycle and cell cycle control | 27 | 0.22 | 0.22 | 0.19 | 43 | 0.14 | 0.14 | 0.02 | 18 | 14 | 5 | 1 | 5 |
Nitrogen and sulfur metabolism | 14 | 0.14 | 0.14 | 0.07 | 28 | 0.39 | 0.39 | 0.32 | 5 | 9 | 6 | 6 | 2 |
Cellular import | 18 | 0.11 | 0.11 | 0.06 | 21 | 0.29 | 0.29 | 0.14 | 5 | 9 | 5 | 2 | 0 |
Stress response | 18 | 0.11 | 0.11 | 0.11 | 29 | 0.1 | 0.07 | 0.07 | 12 | 8 | 5 | 1 | 3 |
Meiosis | 20 | 0.1 | 0.1 | 0.1 | 26 | 0.04 | 0.04 | 0 | 12 | 7 | 2 | 1 | 4 |
mRNA synthesis | 34 | 0.06 | 0.06 | 0.03 | 64 | 0.16 | 0.11 | 0.06 | 30 | 18 | 6 | 1 | 9 |
Lipid, fatty-acid and isoprenoid metabolism | 30 | 0.03 | 0.03 | 0.03 | 39 | 0.13 | 0.13 | 0.05 | 20 | 8 | 5 | 4 | 2 |
DNA recombination and DNA repair | 11 | 0 | 0 | 0 | 19 | 0.05 | 0.05 | 0 | 10 | 4 | 3 | 1 | 1 |
Sporulation and germination | 8 | 0 | 0 | 0 | 17 | 0.12 | 0.06 | 0 | 5 | 6 | 2 | 2 | 2 |
See caption for Table 1 for details. The functional classes were obtained from the MIPS database (Mewes et al. 2002).