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. 2003 Nov;13(11):2455–2466. doi: 10.1101/gr.1212003

Table 3.

Most Frequently Used Metabolites in the E. coli Metabolism

E. coli set
Ouzounis and Karp (2000)
Compound Occurrences Compound Occurrences
H2O 392 H2O 205 (272)
ATP 186 ATP 152 (179)
NAD+ 157 ADP 101 (114)
NADH 153 Phosphate 100 (110)
ADP 133 Pyrophosphate 89 (103)
Pi 123 NAD 66 (91)
PPi 92 NADH 60 (82)
CO2 84 CO2 54 (71)
NADP+ 72 H+ 53 (74)
NADPH 70 AMP 49 (56)
O2 65 NH3 48 (55)
CoA 61 NADP 48 (60)
NH3 60 NADPH 45 (59)
l-Glu 52 Coenzyme A 44 (54)
Pyruvate 49 l-Glutamate 43 (47)
AMP 48 Pyruvate 41 (46)
Acetyl-CoA 33 Acetyl-CoA 29 (33)
KetoGlu 32 O2 26 (36)
Gal 25 2-Oxoglutarate 24 (29)
Acetate 22 s-Adenosyl-l-Methionine 23 (30)

Compound names on the right conform to Ouzounis and Karp (2000).