Figure 3.

Screening DNA-damage phenotypes against a scaffold of molecular interactions. A large molecular interaction network was integrated with 1615 yeast deletion phenotypes gathered systematically in response to MMS exposure. (a) Cytoscape's filter toolbox was first used to show only those proteins required for viable growth in MMS (i.e., MMS-essential proteins) and their immediate network neighbors. (b) The filtered network was then searched using the ActiveModules plug-in to identify interaction complexes containing significant numbers of MMS-essential proteins. One such region is shown, along with its corresponding p-value. Dark gray nodes represent MMS-essential proteins.