Table 4.
Clinical Characteristics of Subjects With ARMC5-Damaging Mutations Compared With Those Without and/or With Nonpathogenic Mutations
| ARMC5 (n = 7) |
No ARMC5 (n = 27) |
P Value | |
|---|---|---|---|
| Mean (±SD) | Mean (±SD) | ||
| Age at the time of biochemical testing (Liddle's), y | 48.7 ± 7.6 | 50.8 ± 12.9 | .69 |
| SBP, mm Hg | 152.4 ± 17.9 | 135.2 ± 20.7 | .053 |
| BMI, kg/m2 | 39.2 ± 12.4 | 34.1 ± 7.3 | .16 |
| 17OHS/Cr, mg/d·g Cr (average 1–2 d) | 11.5 ± 7.9 | 7.3 ± 3.5 | .22 |
| 17OHS/Cr, mg/d·g Cr (after dexamethasone) | 10.5 ± 5.7 | 5.1 ± 4.6 | .014a |
| 17OHS suppression, % | −0.7 ± 41.1 | −22.1 ± 80.2 | .5 |
| UFC/BSA, μg/d·m2 (average 1–2 d) | 51.4 ± 62.6 | 31 ± 36.7 | .33 |
| UFC/BSA, μg/d·m2 (after dexamethasone) | 55.7 ± 83.1 | 20.5 ± 41.4 | .4 |
| UFC suppression, % | −12.4 ± 48 | −39 ± 75.1 | .46 |
| ACTH, pg/mL | 5.6 ± 3.6 | 12.2 ± 10 | .031a |
| Morning cortisol, μg/dL (average) | 15.5 ± 7.8 | 13.5 ± 3.7 | .53 |
| Late-night cortisol, μg/dL (average) | 14.5 ± 5.6 | 6.7 ± 4.3 | <.001a |
| Left adrenal weight, g | 80 ± 47.3 | 40.4 ± 30.1 | .066 |
| Right adrenal weight, g | 84.3 ± 81.1 | 47 ± 28 | .32 |
Abbreviations: BMI, body mass index; SBP, systolic blood pressure.
a
Statistically significant.