Table 1.
Expression of Biomarkers in Pancreatic Ductal Adenocarcinoma Related to Histologic Grade of Tumor
| PAM4, No. (%) | MUC1, No. (%) | MUC4, No. (%) | CEACAM5/6, No. (%) | CA19-9, No. (%) | |
|---|---|---|---|---|---|
| All grades (N = 43/42)a | |||||
| Total labeled | 34 (79) | 43 (100) | 29 (67) | 38 (90) | 39 (91) |
| Focalb | 8 (19) | 1 (2) | 4 (9) | 3 (7) | 2 (5) |
| Diffuse | 26 (60) | 42 (98) | 25 (58) | 35 (83) | 37 (86) |
| Grade 1 (n = 15/14)a | |||||
| Total labeled | 14 (93) | 15 (100) | 10 (67) | 13 (87) | 14 (93) |
| Focal | 4 (27) | 0 | 1 (7) | 0 | 0 |
| Diffuse | 10 (67) | 15 (100) | 9 (60) | 13 (87) | 14 (93) |
| Grade 2 (n = 20) | |||||
| Total labeled | 14 (70) | 20 (100) | 15 (75) | 19 (95) | 18 (90) |
| Focal | 1 (5) | 0 | 3 (15) | 2 (10) | 0 |
| Diffuse | 13 (65) | 20 (100) | 12 (60) | 17 (85) | 18 (90) |
| Grade 3 (n = 8) | |||||
| Total labeled | 6 (75) | 8 (100) | 4 (50) | 6 (75) | 7 (88) |
| Focal | 3 (38) | 1 (13) | 0 | 1 (13) | 2 (25) |
| Diffuse | 3 (38) | 7 (88) | 4 (50) | 5 (63) | 5 (63) |
| Adjacent normal (n = 14) | 0 | 14 (100) | 6 (43) | 14 (100) | 14 (100) |
a
All grades, N=43 for all biomarkers except CEACAM5/6, for which N=42; grade 1, n=15 for all biomarkers except CEACAM5/6, for which N=14.
b
Focal labeling, 5% to 25% of the pancreatic ductal adenocarcinoma tissue labeled with the indicated monoclonal antibody; diffuse, >25% of the pancreatic ductal adenocarcinoma tissue labeled with the indicated monoclonal antibody; total, focal þ diffuse.