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. 2014 May 22;15:169. doi: 10.1186/1471-2474-15-169

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Copyright © 2014 Schmal et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Decreasing intraarticular levels of IGF-1R are observed with progress of OA measured by radiological changes (Kellgren Lawrence Score) of the ankle in patients with OCD. Results of the Spearman correlation are indicated for absolute IGF-1R levels and concentrations in relation to the total protein content (TPC) on the bottom. The S-shaped association was visualized using a smoothing spline regression curve. By combining the data of KLS 0–1 and 2–3, the Kruskal-Wallis H-Test confirmed the statistically significant difference (p = 0.032).