Table 3. Summary of significantly associated small RNAs with metastasis status per group.
|
Non-
vs
metastasised (lymphogenic and occult,
n=38) |
Non-
vs
lymphogenic metastasised (n=35) |
Non-
vs
occult metastasised (n=32) |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Small RNA | P-value | Fold change | 95% Confidence interval | Small RNA | P-value | Fold change | 95% Confidence interval | Small RNA | P-value | Fold change | 95% Confidence interval | |||
| Let-7b |
0.043 |
0.48 |
0.25 |
0.91 |
Mir-18a |
0.003 |
5.00 |
2.31 |
10.82 |
Mir-18a |
0.034 |
3.19 |
1.31 |
7.79 |
| Mir-17 |
0.044 |
2.34 |
1.11 |
4.96 |
Mir-25 |
0.001 |
3.57 |
2.17 |
5.89 |
Mir-25 |
0.004 |
3.81 |
1.97 |
7.38 |
| Mir-18a |
0.008 |
4.10 |
1.70 |
9.85 |
Mir-29a |
0.005 |
0.42 |
0.27 |
0.65 |
Mir-29a |
0.019 |
0.36 |
0.18 |
0.71 |
| Mir-25 |
0.0004 |
3.69 |
2.15 |
6.34 |
Mir-92a-1 |
0.017 |
2.65 |
1.41 |
5.00 |
Mir-92a-1 |
0.043 |
2.10 |
1.15 |
3.84 |
| Mir-29a |
0.001 |
0.39 |
0.25 |
0.60 |
Mir-92a-2 |
0.015 |
2.73 |
1.44 |
5.18 |
Mir-92a-2 |
0.042 |
2.14 |
1.16 |
3.95 |
| Mir-92a-1 |
0.007 |
2.38 |
1.41 |
4.02 |
Mir-93 |
0.050 |
6.24 |
1.32 |
29.48 |
Mir-99a |
0.029 |
0.18 |
0.05 |
0.64 |
| Mir-92a-2 |
0.006 |
2.43 |
1.42 |
4.16 |
Mir-99a |
0.011 |
0.18 |
0.06 |
0.50 |
Mir-29b-1 |
0.046 |
0.37 |
0.16 |
0.85 |
| Mir-99a |
0.001 |
0.18 |
0.08 |
0.40 |
Mir-197 |
0.011 |
2.38 |
1.42 |
4.00 |
Mir-29b-2 |
0.044 |
0.36 |
0.16 |
0.84 |
| Mir-29b-1 |
0.012 |
0.45 |
0.27 |
0.77 |
Mir-148a |
0.036 |
2.51 |
1.23 |
5.13 |
Mir-182 |
0.018 |
3.43 |
1.52 |
7.76 |
| Mir-29b-2 |
0.012 |
0.46 |
0.27 |
0.77 |
Mir-30c-2 |
0.033 |
2.81 |
1.28 |
6.17 |
Mir-125b-1 |
0.040 |
0.22 |
0.07 |
0.74 |
| Mir-30c-2 |
0.038 |
2.41 |
1.14 |
5.08 |
Mir-30d |
0.024 |
2.27 |
1.27 |
4.05 |
Mir-128-1 |
0.029 |
3.19 |
1.36 |
7.49 |
| Mir-182 |
0.008 |
3.35 |
1.57 |
7.14 |
Mir-7-1 |
0.028 |
3.64 |
1.41 |
9.40 |
Mir-125b-2 |
0.040 |
0.22 |
0.07 |
0.74 |
| Mir-183 |
0.037 |
5.22 |
1.29 |
21.04 |
Mir-182 |
0.015 |
3.26 |
1.54 |
6.90 |
Mir-320a |
0.035 |
2.59 |
1.24 |
5.41 |
| Mir-15b |
0.024 |
2.65 |
1.26 |
5.58 |
Mir-183 |
0.003 |
4.39 |
2.18 |
8.86 |
Mir-128-2 |
0.034 |
3.20 |
1.31 |
7.81 |
| Mir-125b-1 |
0.006 |
0.31 |
0.16 |
0.63 |
Mir-15b |
0.002 |
2.77 |
1.77 |
4.32 |
Mir-106b |
0.001 |
5.22 |
2.69 |
10.13 |
| Mir-128-1 |
0.012 |
3.86 |
1.56 |
9.55 |
Mir-128-1 |
0.009 |
4.53 |
1.91 |
10.74 |
Mir-29c |
0.019 |
0.30 |
0.13 |
0.67 |
| Mir-145 |
0.023 |
0.50 |
0.29 |
0.85 |
Mir-128-2 |
0.009 |
4.77 |
1.97 |
11.54 |
Mir-296 |
0.017 |
4.01 |
1.62 |
9.90 |
| Mir-125b-2 |
0.006 |
0.31 |
0.16 |
0.63 |
Mir-106b |
0.003 |
6.63 |
2.71 |
16.23 |
Mir-326 |
0.004 |
2.61 |
1.63 |
4.17 |
| Mir-150 |
0.028 |
0.36 |
0.16 |
0.81 |
Mir-30c-1 |
0.033 |
2.80 |
1.28 |
6.12 |
Mir-151a |
0.015 |
2.35 |
1.37 |
4.04 |
| Mir-128-2 |
0.014 |
3.98 |
1.53 |
10.36 |
Mir-296 |
0.019 |
3.78 |
1.55 |
9.20 |
Mir-331 |
0.033 |
2.58 |
1.25 |
5.30 |
| Mir-106b |
0.001 |
5.92 |
2.49 |
14.11 |
Mir-130b |
0.045 |
2.95 |
1.21 |
7.18 |
Mir-484 |
0.016 |
2.06 |
1.29 |
3.27 |
| Mir-29c |
0.005 |
0.40 |
0.24 |
0.68 |
Mir-378a |
0.015 |
2.66 |
1.43 |
4.95 |
Mir-505 |
0.006 |
2.65 |
1.59 |
4.42 |
| Mir-30c-1 |
0.037 |
2.41 |
1.15 |
5.06 |
Mir-340 |
0.0002 |
3.42 |
2.34 |
4.98 |
Mir-92b |
0.014 |
3.10 |
1.53 |
6.31 |
| Mir-296 |
0.007 |
3.89 |
1.71 |
8.87 |
Mir-326 |
0.002 |
3.63 |
2.12 |
6.21 |
Mir-652 |
0.022 |
3.23 |
1.44 |
7.24 |
| Mir-378a |
0.028 |
2.32 |
1.19 |
4.53 |
Mir-331 |
0.001 |
3.05 |
1.96 |
4.74 |
ENST00000516461 |
0.045 |
2.53 |
1.18 |
5.44 |
| Mir-340 |
0.006 |
3.12 |
1.58 |
6.18 |
Mir-345 |
0.035 |
3.26 |
1.31 |
8.12 |
ENST00000516775 |
0.045 |
2.54 |
1.18 |
5.47 |
| Mir-326 |
0.001 |
3.12 |
1.82 |
5.33 |
Mir-423 |
0.001 |
2.24 |
1.65 |
3.02 |
ENST00000517209 |
0.046 |
7.07 |
1.39 |
35.98 |
| Mir-151a |
0.023 |
2.32 |
1.22 |
4.39 |
Mir-484 |
0.015 |
2.28 |
1.35 |
3.85 |
ENST00000387347 |
0.050 |
2.77 |
1.17 |
6.57 |
| Mir-331 |
0.003 |
2.81 |
1.61 |
4.92 |
Mir-505 |
0.002 |
3.62 |
2.03 |
6.47 |
ENST00000474885 |
0.001 |
3.38 |
2.05 |
5.56 |
| Mir-484 |
0.003 |
2.17 |
1.43 |
3.29 |
Mir-92b |
0.015 |
4.76 |
1.76 |
12.89 |
ENST00000459522 |
0.001 |
3.35 |
2.04 |
5.52 |
| Mir-505 |
0.002 |
3.13 |
1.72 |
5.71 |
Mir-625 |
0.041 |
3.47 |
1.28 |
9.42 |
ENST00000488123 |
0.039 |
2.89 |
1.24 |
6.72 |
| Mir-92b |
0.016 |
3.93 |
1.48 |
10.40 |
Mir-421 |
0.025 |
2.77 |
1.34 |
5.70 |
ENST00000463796 |
0.013 |
4.19 |
1.73 |
10.17 |
| Mir-652 |
0.035 |
2.77 |
1.19 |
6.45 |
Mir-744 |
0.023 |
2.14 |
1.26 |
3.63 |
|
|
|
|
|
| ENST00000387347 |
0.013 |
2.84 |
1.39 |
5.79 |
ENST00000387347 |
0.005 |
2.91 |
1.68 |
5.06 |
|
|
|
|
|
| ENST00000474885 |
0.014 |
2.99 |
1.40 |
6.41 |
ENST00000466665 |
0.027 |
2.50 |
1.28 |
4.87 |
|
|
|
|
|
| ENST00000459522 |
0.015 |
2.97 |
1.39 |
6.37 |
|
|
|
|
|
|
|
|
|
|
| ENST00000463796 |
0.034 |
3.79 |
1.26 |
11.44 |
|
|
|
|
|
|
|
|
|
|
| ENST00000466665 | 0.046 | 2.27 | 1.09 | 4.71 | ||||||||||