Table 4. Summary on combinations of two small RNAs, which together allow to discriminate completely metastasis subtypes (lymphogenic and occult) and their combination from non-metastasised seminoma.
Non-
vs
metastasised (lymphogenic and occult,
n=6) |
Non- vs
lymphogenic metastasised (n=125) |
Non-
vs
occult metastasised (n=52) |
|||
---|---|---|---|---|---|
Small RNA1 | Small RNA2 | Small RNA1 | Small RNA2 | Small RNA1 | Small RNA2 |
Mir-29a |
Enst00000387347 |
Let-7a-1 |
Mir-99a |
Let-7b |
ENST00000466665 |
Mir-150 |
Mir-3676 |
Let-7a-2 |
Mir-99a |
Mir-15a |
ENST00000387347 |
Mir-150 |
Enst00000516461 |
Let-7a-3 |
Mir-99a |
Mir-16-1 |
Mir-128-1 |
Mir-150 |
Enst00000516775 |
Let-7b |
Mir-331 |
Mir-16-1 |
Mir-128-2 |
Mir-29c |
Enst00000387347 |
Mir-15a |
Mir-331 |
Mir-16-1 |
Mir-361 |
Mir-342 |
Mir-326 |
Mir-16-1 |
Mir-331 |
Mir-16-1 |
Mir-652 |
|
|
Mir-18a |
Mir-99a |
Mir-19b-2 |
Mir-25 |
|
|
Mir-22 |
Mir-99a |
Mir-24-1 |
ENST00000466665 |
|
|
Mir-23a |
Mir-99a |
Mir-24-2 |
ENST00000466665 |
|
|
Mir-24-1 |
Mir-326 |
Mir-25 |
Mir-126 |
|
|
Mir-24-1 |
Mir-331 |
Mir-25 |
Mir-342 |
|
|
Mir-24-2 |
Mir-326 |
Mir-26a-1 |
ENST00000466665 |
|
|
Mir-24-2 |
Mir-331 |
Mir-29a |
Mir-326 |
|
|
Mir-25 |
Mir-29a |
Mir-29a |
Mir-4454 |
|
|
Mir-25 |
Mir-29b-1 |
Mir-29a |
ENST00000474885 |
|
|
Mir-25 |
Mir-29b-2 |
Mir-29a |
ENST00000459522 |
|
|
Mir-25 |
Mir-222 |
Mir-29a |
ENST00000459949 |
|
|
Mir-25 |
Mir-29c |
Mir-29a |
ENST00000463796 |
|
|
Mir-29a |
Mir-148a |
Mir-29a |
ENST00000466665 |
|
|
Mir-29a |
Mir-183 |
Mir-92a-1 |
Mir-150 |
|
|
Mir-29a |
Mir-15b |
Mir-92a-2 |
Mir-150 |
|
|
Mir-29a |
Mir-128-1 |
Mir-99a |
Mir-320a |
|
|
Mir-29a |
Mir-128-2 |
Mir-99a |
ENST00000466665 |
|
|
Mir-29a |
Mir-296 |
Mir-29b-1 |
Mir-326 |
|
|
Mir-29a |
Mir-378a |
Mir-29b-1 |
Mir-505 |
|
|
Mir-29a |
Mir-340 |
Mir-29b-1 |
ENST00000474885 |
|
|
Mir-29a |
Mir-331 |
Mir-29b-1 |
ENST00000459522 |
|
|
Mir-29a |
Mir-423 |
Mir-29b-2 |
Mir-326 |
|
|
Mir-29a |
Mir-425 |
Mir-29b-2 |
Mir-505 |
|
|
Mir-29a |
Mir-625 |
Mir-29b-2 |
ENST00000474885 |
|
|
Mir-29a |
Mir-421 |
Mir-29b-2 |
ENST00000459522 |
|
|
Mir-29a |
Mir-744 |
Mir-182 |
Mir-342 |
|
|
Mir-29a |
ENST00000387347 |
Mir-181a-1 |
Mir-106b |
|
|
Mir-92a-2 |
Mir-29b-1 |
Let-7g |
Mir-128-2 |
|
|
Mir-92a-2 |
Mir-29b-2 |
Let-7g |
Mir-106b |
|
|
Mir-93 |
Mir-182 |
Let-7g |
Mir-378a |
|
|
Mir-93 |
Mir-183 |
Let-7g |
Mir-505 |
|
|
Mir-93 |
Mir-340 |
Let-7g |
ENST00000387347 |
|
|
Mir-93 |
ENST00000488123 |
Mir-30b |
Mir-30e |
|
|
Mir-93 |
ENST00000463796 |
Mir-150 |
Mir-320a |
|
|
Mir-93 |
ENST00000466665 |
Mir-150 |
Mir-3676 |
|
|
Mir-99a |
Mir-107 |
Mir-150 |
ENST00000516461 |
|
|
Mir-99a |
Mir-30c-2 |
Mir-150 |
ENST00000516775 |
|
|
Mir-99a |
Mir-15b |
Mir-106b |
Mir-660 |
|
|
Mir-99a |
Mir-128-1 |
Mir-29c |
Mir-505 |
|
|
Mir-99a |
Mir-128-2 |
Mir-29c |
ENST00000474885 |
|
|
Mir-99a |
Mir-30c-1 |
Mir-29c |
ENST00000459522 |
|
|
Mir-99a |
Mir-361 |
Mir-296 |
Mir-342 |
|
|
Mir-99a |
Mir-331 |
Mir-26a-2 |
ENST00000466665 |
|
|
Mir-99a |
Mir-339 |
Mir-342 |
Mir-151a |
|
|
Mir-99a |
Mir-425 |
Mir-342 |
ENST00000474885 |
|
|
Mir-99a |
Mir-505 |
Mir-342 |
ENST00000459522 |
|
|
Mir-99a |
ENST00000516881 |
|
|
|
|
Mir-29b-1 |
Mir-30c-2 |
|
|
|
|
Mir-29b-1 |
Mir-30d |
|
|
|
|
Mir-29b-1 |
Mir-15b |
|
|
|
|
Mir-29b-1 |
Mir-128-1 |
|
|
|
|
Mir-29b-1 |
Mir-128-2 |
|
|
|
|
Mir-29b-1 |
Mir-30c-1 |
|
|
|
|
Mir-29b-1 |
Mir-331 |
|
|
|
|
Mir-29b-1 |
Mir-425 |
|
|
|
|
Mir-29b-1 |
Mir-505 |
|
|
|
|
Mir-29b-1 |
ENST00000387347 |
|
|
|
|
Mir-29b-2 |
Mir-30c-2 |
|
|
|
|
Mir-29b-2 |
Mir-30d |
|
|
|
|
Mir-29b-2 |
Mir-15b |
|
|
|
|
Mir-29b-2 |
Mir-128-1 |
|
|
|
|
Mir-29b-2 |
Mir-128-2 |
|
|
|
|
Mir-29b-2 |
Mir-30c-1 |
|
|
|
|
Mir-29b-2 |
Mir-331 |
|
|
|
|
Mir-29b-2 |
Mir-425 |
|
|
|
|
Mir-29b-2 |
Mir-505 |
|
|
|
|
Mir-29b-2 |
ENST00000387347 |
|
|
|
|
Mir-16-2 |
Mir-331 |
|
|
|
|
Mir-16-2 |
ENST00000387347 |
|
|
|
|
Mir-197 |
Mir-150 |
|
|
|
|
Mir-182 |
Mir-142 |
|
|
|
|
Mir-183 |
Mir-142 |
|
|
|
|
Mir-183 |
ENST00000365160 |
|
|
|
|
Mir-181a-1 |
Mir-331 |
|
|
|
|
Mir-221 |
Mir-331 |
|
|
|
|
Mir-222 |
Mir-128-2 |
|
|
|
|
Mir-222 |
Mir-106b |
|
|
|
|
Mir-222 |
Mir-331 |
|
|
|
|
Mir-222 |
ENST00000387347 |
|
|
|
|
Let-7g |
Mir-15b |
|
|
|
|
Let-7g |
Mir-128-1 |
|
|
|
|
Let-7g |
Mir-331 |
|
|
|
|
Mir-23b |
Mir-331 |
|
|
|
|
Mir-125b-1 |
Mir-331 |
|
|
|
|
Mir-128-1 |
Mir-29c |
|
|
|
|
Mir-142 |
Mir-130b |
|
|
|
|
Mir-142 |
Mir-326 |
|
|
|
|
Mir-142 |
Mir-421 |
|
|
|
|
Mir-142 |
Mir-1260b |
|
|
|
|
Mir-142 |
ENST00000387347 |
|
|
|
|
Mir-142 |
ENST00000516881 |
|
|
|
|
Mir-145 |
Mir-331 |
|
|
|
|
Mir-125b-2 |
Mir-331 |
|
|
|
|
Mir-126 |
Mir-331 |
|
|
|
|
Mir-150 |
Mir-130b |
|
|
|
|
Mir-150 |
Mir-331 |
|
|
|
|
Mir-150 |
Mir-345 |
|
|
|
|
Mir-150 |
Mir-421 |
|
|
|
|
Mir-150 |
Mir-766 |
|
|
|
|
Mir-150 |
Mir-744 |
|
|
|
|
Mir-150 |
Mir-1260b |
|
|
|
|
Mir-150 |
Mir-3676 |
|
|
|
|
Mir-150 |
ENST00000516461 |
|
|
|
|
Mir-150 |
ENST00000516775 |
|
|
|
|
Mir-150 |
ENST00000387347 |
|
|
|
|
Mir-150 |
ENST00000410361 |
|
|
|
|
Mir-150 |
ENST00000431311 |
|
|
|
|
Mir-128-2 |
Mir-29c |
|
|
|
|
Mir-29c |
Mir-378a |
|
|
|
|
Mir-29c |
Mir-326 |
|
|
|
|
Mir-29c |
Mir-331 |
|
|
|
|
Mir-29c |
Mir-425 |
|
|
|
|
Mir-29c |
Mir-744 |
|
|
|
|
Mir-29c |
ENST00000387347 |
|
|
|
|
Mir-328 |
Mir-331 |
|
|
|
|
Mir-148b |
ENST00000365160 |
|
|
|
|
Mir-331 |
Mir-574 |
|
|
|
|
Mir-331 |
Mir-660 |
|
|
Mir-425 | Mir-660 |
The total number of small RNA combinations per group is shown within parentheses.