Table 2. Associations between common infection-related conditions and non-Hodgkin lymphoma (combined and by main subtypes) and Hodgkin lymphoma.
| |
|
NHL subtypes |
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |
Controls |
Overall NHL (n=44 191) |
Diffuse large B- cell lymphoma (n=15 883) |
T-cell NHL (n=2813) |
Follicular lymphoma (n=4491) |
Marginal zone lymphoma (n=3223) |
Hodgkin lymphoma (n=1832) |
||||||
| Infection-related conditions by site | No. | No. | OR (95% CI)a | No. | OR (95% CI)a | No. | OR (95% CI)a | No. | OR (95% CI)a | No. | OR (95% CI)a | No. | OR (95% CI)a |
|
Respiratory tract | |||||||||||||
| Common cold | 7322 | 1801 | 1.06 (1.00–1.12) | 624 | 1.00 (0.92–1.09) | 119 | 1.12 (0.93–1.35) | 279 | 1.02 (0.91–1.16) | 171 | 1.24 (1.06–1.45) | 66 | 0.97 (0.76–1.25) |
| Sinusitis | 36 249 | 9464 | 1.17 (1.13–1.20) | 3389 | 1.14 (1.09–1.19) | 544 | 1.04 (0.94–1.14) | 1560 | 1.16 (1.10–1.24) | 853 | 1.32 (1.21–1.43) | 380 | 1.15 (1.02–1.29) |
| Laryngitis | 6584 | 1810 | 1.17 (1.11–1.24) | 652 | 1.15 (1.06–1.25) | 119 | 1.26 (1.04–1.51) | 310 | 1.25 (1.11–1.41) | 157 | 1.23 (1.05–1.45) | 75 | 1.23 (0.97–1.55) |
| Pharyngitis | 22 472 | 5695 | 1.11 (1.07–1.15) | 1959 | 1.03 (0.98–1.09) | 396 | 1.25 (1.12–1.39) | 915 | 1.09 (1.01–1.17) | 476 | 1.14 (1.03–1.26) | 240 | 1.17 (1.02–1.34) |
| Bronchitis | 45 215 | 11 458 | 1.13 (1.10–1.16) | 4123 | 1.11 (1.06–1.15) | 704 | 1.10 (1.01–1.21) | 1779 | 1.08 (1.02–1.15) | 939 | 1.15 (1.07–1.25) | 446 | 1.09 (0.98–1.22) |
| Influenza | 14 726 | 3892 | 1.15 (1.11–1.19) | 1389 | 1.11 (1.05–1.18) | 255 | 1.21 (1.06–1.38) | 628 | 1.16 (1.06–1.26) | 370 | 1.33 (1.19–1.49) | 157 | 1.17 (0.99–1.38) |
| Pneumonia |
30 201 |
7556 |
1.10 (1.07–1.14) |
2679 |
1.05 (1.01–1.10) |
448 |
1.04 (0.94–1.16) |
1093 |
1.03 (0.96–1.10) |
633 |
1.22 (1.11–1.34) |
280 |
1.05 (0.92–1.19) |
|
Skin | |||||||||||||
| Cellulitis | 34 426 | 8939 | 1.15 (1.12–1.18) | 3176 | 1.09 (1.05–1.14) | 627 | 1.36 (1.24–1.49) | 1352 | 1.10 (1.04–1.18) | 751 | 1.23 (1.13–1.34) | 345 | 1.13 (1.00–1.28) |
| Herpes zoster |
8557 |
2553 |
1.28 (1.22–1.35) |
889 |
1.20 (1.12–1.30) |
153 |
1.25 (1.06–1.48) |
386 |
1.24 (1.11–1.38) |
200 |
1.22 (1.06–1.42) |
118 |
1.55 (1.28–1.87) |
|
Gastrointestinal tract | |||||||||||||
| Gingivitis | 917 | 209 | 0.98 (0.84–1.14) | 89 | 1.14 (0.92–1.43) | <11 | 0.67 (0.35–1.30) | 24 | 0.70 (0.46–1.05) | 89 | 1.14 (0.92–1.43) | <11 | 0.94 (0.47–1.89) |
| Gastroenteritis |
5312 |
1299 |
1.03 (0.96–1.10) |
488 |
1.04 (0.95–1.15) |
79 |
1.03 (0.82–1.30) |
175 |
0.88 (0.75–1.02) |
107 |
1.04 (0.85–1.26) |
62 |
1.27 (0.99–1.65) |
|
Urinary tract | |||||||||||||
| Cystitisb | 35 283 | 13 876 | 1.04 (1.02–1.07) | 3410 | 1.01 (0.96–1.06) | 494 | 1.05 (0.93–1.18) | 1536 | 1.02 (0.96–1.09) | 794 | 1.05 (0.96–1.16) | 565 | 1.11 (1.00–1.23) |
| Prostatitisc | 16 203 | 3620 | 1.12 (1.07–1.17) | 1194 | 1.02 (0.96–1.09) | 256 | 1.05 (0.91–1.20) | 555 | 1.19 (1.08–1.31) | 246 | 1.05 (0.91–1.21) | 128 | 0.96 (0.79–1.16) |
| Pyelonephritisb | 2184 | 799 | 0.95 (0.88–1.03) | 214 | 1.01 (0.88–1.17) | 34 | 1.14 (0.81–1.61) | 74 | 0.79 (0.62–0.99) | 37 | 0.77 (0.55–1.07) | 20 | 0.91 (0.58–1.42) |
Abbreviations: CI=confidence interval; NHL=non-Hodgkin lymphoma; OR=odds ratio.
Associations significant following Bonferroni correct (P<0.00045) are underlined.
Observations, in which the number of exposed patients is between 1 and 10, are listed as ‘<11' to preserve subjects' anonymity, in accordance with the SEER-Medicare data use agreement.
a
ORs and 95% CIs were adjusted for age (66–69, 70–74, 75–79, 80–84 and 85–99 years), gender and diagnosis/selection year.
b
Females only.
c
Males only.