Table 4. Association between common infection-related conditions and risk of non-Hodgkin lymphoma/Hodgkin lymphoma by the time of claim before diagnosis.
| Infection-related conditions by site | 13–30 months OR (95% CI)a | 31–48 months OR (95% CI)a | 49–72 months OR (95% CI)a | >72 months OR (95% CI)a |
|---|---|---|---|---|
|
Non-Hodgkin lymphoma | ||||
| Sinusitis | 1.11 (1.05–1.16) | 1.30 (1.23–1.37) | 1.18 (1.12–1.23) | 1.12 (1.07–1.17) |
| Laryngitis | 1.10 (0.99–1.22) | 1.34 (1.20–1.49) | 1.16 (1.05–1.29) | 1.13 (1.01–1.26) |
| Pharyngitis | 1.04 (0.97–1.10) | 1.21 (1.13–1.29) | 1.12 (1.06–1.19) | 1.09 (1.03–1.16) |
| Bronchitis | 1.05 (1.00–1.10) | 1.25 (1.19–1.31) | 1.15 (1.10–1.19) | 1.12 (1.08–1.17) |
| Influenza | 1.26 (1.20–1.32) | 1.08 (0.98–1.20) | 1.00 (0.92–1.10) | 1.07 (0.99–1.17) |
| Pneumonia | 1.05 1.00–1.10) | 1.18 (1.12–1.25) | 1.08 (1.02–1.14) | 1.14 (1.08–1.20) |
| Cellulitis | 1.11 (1.06–1.16) | 1.14 (1.09–1.20) | 1.17 (1.11–1.23) | 1.18 (1.12–1.24) |
| Herpes zoster | 1.29 (1.19–1.40) | 1.36 (1.24–1.49) | 1.24 (1.13–1.36) | 1.24 (1.13–1.37) |
| Prostatitis |
1.07 (1.00–1.16) |
1.12 (1.03–1.21) |
1.11 (1.03–1.20) |
1.17 (1.09–1.25) |
|
Diffuse large B-cell lymphoma | ||||
| Sinusitis | 1.09 (1.01–1.18) | 1.28 (1.19–1.39) | 1.15 (1.07–1.23) | 1.08 (1.00–1.15) |
| Bronchitis | 1.04 (0.97–1.11) | 1.15 (1.07–1.24) | 1.11 (1.04–1.19) | 1.13 (1.06–1.21) |
| Influenza | 1.21 (1.11–1.31) | 0.98 (0.84–1.14) | 1.04 (0.91–1.18) | 1.07 (0.94–1.21) |
| Cellulitis | 1.05 (0.98–1.13) | 1.08 (1.00–1.17) | 1.13 (1.05–1.22) | 1.12 (1.03–1.21) |
| Herpes zoster |
1.13 (0.99–1.29) |
1.26 (1.09–1.46) |
1.28 (1.11–1.46) |
1.16 (1.00–1.35) |
|
T-cell NHL | ||||
| Pharyngitis | 1.24 (1.01–1.52) | 1.26 (1.00–1.57) | 1.34 (1.10–1.62) | 1.17 (0.96–1.43) |
| Cellulitis |
1.33 (1.14–1.56) |
1.42 (1.20–1.67) |
1.41 (1.20–1.66) |
1.29 (1.08–1.54) |
|
Follicular lymphoma | ||||
| Sinusitis | 1.10 (0.99–1.22) | 1.35 (1.21–1.51) | 1.10 (0.99–1.22) | 1.16 (1.05–1.29) |
| Laryngitis | 1.14 (0.90–1.43) | 1.25 (0.97–1.60) | 1.30 (1.04–1.63) | 1.33 (1.06–1.67) |
| Herpes zoster |
1.40 (1.18–1.68) |
1.24 (1.00–1.53) |
1.02 (0.81–1.28) |
1.25 (1.00–1.55) |
|
Marginal zone lymphoma | ||||
| Sinusitis | 1.50 (1.30–1.72) | 1.34 (1.14–1.57) | 1.32 (1.15–1.51) | 1.16 (1.01–1.33) |
| Bronchitis | 1.13 (0.98–1.30) | 1.23 (1.06–1.43) | 1.21 (1.07–1.38) | 1.07 (0.94–1.23) |
| Influenza | 1.37 (1.18–1.60) | 1.53 (1.17–2.01) | 1.18 (0.91–1.52) | 1.25 (0.99–1.59) |
| Pneumonia | 1.25 (1.07–1.46) | 1.32 (1.11–1.57) | 1.05 (0.88–1.25) | 1.27 (1.08–1.49) |
| Cellulitis |
1.29 (1.12–1.50) |
1.23 (1.05–1.44) |
1.24 (1.07–1.44) |
1.16 (0.99–1.35) |
|
Hodgkin lymphoma | ||||
| Herpes zoster | 1.36 (0.95–1.94) | 1.48 (1.00–2.19) | 1.93 (1.38–2.70) | 1.49 (1.00–2.22) |
Abbreviations: CI=confidence interval; NHL=non-Hodgkin lymphoma; OR=odds ratio.
a
ORs and 95% CIs were adjusted for age (66–69, 70–74, 75–79, 80–84 and 85–99 years), gender and diagnosis/selection year.