Table 2.
IPA analysis of signaling pathways, physiological functions, and molecular/cellular functions associated with flow-induced changes in gene transcripts.
| Top Canonical Pathways | p-value | Ratio | Associated Molecules |
|---|---|---|---|
| ErbB Signaling | 4.66E-04 | 5/90 | Btc, Ereg, Pak3, Pik3r1, Sos1 |
| Focal Adhesion Kinase Signaling | 3.81E-03 | 4/106 | Pak3, Pik3r1, Sos1, Tln1 |
| Neuregulin Signaling | 5.26E-03 | 4/104 | Btc, Ereg, Pik3r1, Sosl |
| Paxillin Signaling | 5.73E-03 | 4/117 | Pak3, Pik3r1, Sos1, Tlnl |
| Role of IL-17A in Arthritis | 7.27E-03 | 3/64 | Cxcl3, Cxcl6, Pik3r1 |
| ERK/MAPK Signaling | 1.04E-02 | 5/211 | Pak3, Pik3r1, Ppp1r14c, Sos1, Tln1 |
| NF-κB Signaling | 4.01E-02 | 4/181 | Irak4, Peli1, Pik3r1, Tirap |
| Physiological System Development and Function | p-value | # Molecules | |
|---|---|---|---|
| Hematological System Development and Function | <4.89E-02 | 21 | |
| Hematopoiesis | <3.41E-02 | 8 | |
| Immune Cell Trafficking | <4.89E-02 | 15 | |
| Connective Tissue Development and Function | <4.25E-02 | 21 |
| Molecular and Cellular Functions | p-value | # Molecules | |
|---|---|---|---|
| Cell Morphology | <4.89E-02 | 20 | |
| Cellular Function and Maintenance | <4.89E-02 | 21 | |
| Cellular Growth and Proliferation | <4.25E-02 | 45 | |
| Cellular Movement | <4.89E-02 | 31 |
Results from Ingenuity Pathway Analysis software deriving gene ontology associations from transcript levels changing >1.25-fold (p<0.1). The software assigns a p-value based on the probability that the functional assignment is due to chance alone. “Ratio” indicates number of molecules from the data set that map to the pathway divided by the total number of molecules that map to the canonical pathway. Under “# Molecules”, a denominator representing number of molecules associated with each function is not reported.