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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2013 Nov;72(11):1009–1015. doi: 10.1097/01.jnen.0000435847.59828.db

Figure 6. Full-length gephyrin expression is reduced in AD insoluble proteome.

Figure 6

The insoluble fraction (urea soluble) from 5 control and 5 AD cases (including cases in Figure 5) were subject to mass spectrometry analysis. Samples were resolved on an acrylamide gel and lanes were divided into 5 different molecular weight regions. Gephyrin peptides were identified in the molecular region consistent with full-length gephyrin. Spectral counts (number of gephyrin peptides sequenced) were normalized following removal of system background. The AD mean is significantly reduced compared to controls (p-value <0.05).