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. Author manuscript; available in PMC: 2014 May 29.
Published in final edited form as: Bioorg Med Chem. 2008 Sep 27;17(4):1764–1771. doi: 10.1016/j.bmc.2008.09.058

Scheme 4.

Scheme 4

Reagents and conditions: (a) Boc-Gly-OH, DIC, cat. DMAP, DCM, 45%; (b) i—LiOH, THF, H2O; ii—TFA, 90%; (c) 20g or 20i, BisBocPCH, Et3N, MeOH, 54%; (d) i—DIC, cat DMAP, DCM; ii—TFA, 57%.